1,1-dimethylethyl 4-[5-chloro-3-[(dimethylamino)methyl]-2-(methoxy)phenyl]piperazine-1-carboxylate

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Chemical Name:1,1-dimethylethyl 4-[5-chloro-3-[(dimethylamino)methyl]-2-(methoxy)phenyl]piperazine-1-carboxylate
CAS No.:871339-06-9
Molecular Formula:C₁₉H₃₀ClN₃O₃
Molecular Weight:383.918
Hs Code.:

Synonyms:1,1-dimethylethyl 4-[5-chloro-3-[(dimethylamino)methyl]-2-(methoxy)phenyl]piperazine-1-carboxylate

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Chemical Property of 1,1-dimethylethyl 4-[5-chloro-3-[(dimethylamino)methyl]-2-(methoxy)phenyl]piperazine-1-carboxylate

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Technology Process of 1,1-dimethylethyl 4-[5-chloro-3-[(dimethylamino)methyl]-2-(methoxy)phenyl]piperazine-1-carboxylate

There total 5 articles about 1,1-dimethylethyl 4-[5-chloro-3-[(dimethylamino)methyl]-2-(methoxy)phenyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 871339-05-8
1,1-dimethylethyl 4-[5-chloro-3-formyl-2-(methoxy)phenyl]piperazine-1-carboxylate

: 506-59-2
N,N-dimethylammonium chloride

: 871339-06-9
1,1-dimethylethyl 4-[5-chloro-3-[(dimethylamino)methyl]-2-(methoxy)phenyl]piperazine-1-carboxylate

Guidance literature:: 1,1-dimethylethyl 4-[5-chloro-3-formyl-2-(methoxy)phenyl]piperazine-1-carboxylate; N,N-dimethylammonium chloride; With titanium(IV) isopropylate; triethylamine; In ethanol; at 20 ℃; for 15h;

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 3h;

Reference yield:

: 65851-97-0
methyl 3-bromo-5-chloro-2-methoxybenzoate

: 871339-06-9
1,1-dimethylethyl 4-[5-chloro-3-[(dimethylamino)methyl]-2-(methoxy)phenyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 24 h / Heating / reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

2.2: 0.17 h / 0 °C

3.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

4.1: titanium(IV) isopropylate; triethylamine / ethanol / 15 h / 20 °C

4.2: 3 h / 20 °C

With titanium(IV) isopropylate; lithium aluminium tetrahydride; caesium carbonate; Dess-Martin periodane; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 871339-06-9
1,1-dimethylethyl 4-[5-chloro-3-[(dimethylamino)methyl]-2-(methoxy)phenyl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 24 h / Heating / reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

2.2: 0.17 h / 0 °C

3.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

4.1: titanium(IV) isopropylate; triethylamine / ethanol / 15 h / 20 °C

4.2: 3 h / 20 °C

With titanium(IV) isopropylate; lithium aluminium tetrahydride; caesium carbonate; Dess-Martin periodane; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; dichloromethane; toluene;