2-Amino-4-methylpentanamide hydrochloride

Base Information

• Chemical Name: 2-Amino-4-methylpentanamide hydrochloride
• CAS No.: 80970-09-8
• Molecular Formula: C6H14 N2 O . Cl H
• Molecular Weight: 166.651
• Hs Code.: 2924199090
• European Community (EC) Number: 865-234-5
• NSC Number: 206279,83635
• Mol file: 80970-09-8.mol

Synonyms:10466-60-1;2-amino-4-methylpentanamide hydrochloride;H-DL-Leu-NH2.HCl;H-DL-LEU-NH2 HCL;DL-Leucinamide hydrochloride;h-dl-leu-nh2hcl;2-amino-4-methylpentanamide;hydrochloride;1668-11-7;DL-Leucine amide hydrochloride;H-D-Leu-NH HCl;H-DL-Leu-NH HCl;H-DL-Leu-NH2 . HCl;(2R)-2-amino-4-methylpentanamide;starbld0026075;H-D-Leu-NH2*HCl;H-dl-Leu-NH2 hydrochloride;SCHEMBL1425296;D,L-leucine amide hydrochloride;VSPSRRBIXFUMOU-UHFFFAOYSA-N;NSC83635;MFCD00070244;NSC-83635;NSC206279;Pentanamide, monohydrochloride, (S)-;AKOS015910946;FD21910;NSC-206279;AS-49238;BP-10460;2-amino-4-methyl-pentanamide hydrochloride;2-azanyl-4-methyl-pentanamide hydrochloride;CS-0154067;FT-0627929;FT-0762062;FT-0772050;EN300-6496579;A801032;A840013;A896187;Pentanamide,2-amino-4-methyl-,hydrochloride(1:1);2-Amino-4-methyl-pentanoic acid amide hydrochloride

Chemical Property of 2-Amino-4-methylpentanamide hydrochloride

Chemical Property:

• Appearance/Colour: white - off-white powder
• Melting Point: >/=220
• Boiling Point: 250.9°Cat760mmHg
• Flash Point: 105.6°C
• PSA: 69.11000
• Density: 0.98g/cm³
• LogP: 2.04770
• Storage Temp.: -15°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 166.0872908
• Heavy Atom Count: 10
• Complexity: 101

Purity/Quality:

97% ^*data from raw suppliers

D-Leucine amide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)N)N.Cl
• Uses: H-D-Leu-NH2 HCl

Technology Process of 2-Amino-4-methylpentanamide hydrochloride

There total 1 articles about 2-Amino-4-methylpentanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(1,3-dicyano-5-isopropenyl-2-methyl-cyclohexylamino)-4-methyl-pentanoic acid amide → (2S)-amino-4-methylpentanamide hydrochloride (10466-61-2) + (R)-2-amino-4-methylpentanamide hydrochloride (80970-09-8)

Guidance literature:

With hydrogenchloride; In methanol; water; at 50 ℃; for 4h; pH=1; Title compound not separated from byproducts;

DOI:10.1002/ejoc.200600294

Reference yield: 90.0%

(R)-2-amino-4-methylpentanamide hydrochloride (80970-09-8) + 4-chlorobenzenesulfonyl chloride (98-60-2) → (R)-2-(4-chlorobenzensulfonylamino)-4-methylpentanoic acid amide (553619-61-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2012.09.057

Reference yield: 89.0%

(R)-2-amino-4-methylpentanamide hydrochloride (80970-09-8) + Moz-Phe-OBzl (137314-55-7) → Moz-Phe-D-Leu-NH2 (145126-22-3)

Guidance literature:

With triethylamine; In tert-butyl alcohol; at 35 ℃; for 2.5h; industrial alkaline protease alcalase;

DOI:10.1021/jo00051a052

Downstream raw materials:

N-CBZ-L-Tyr-D-LeuNH₂

Moz-Phe-D-Leu-NH₂

[(1S,2S,4R)-1-Benzyl-4-((R)-1-carbamoyl-3-methyl-butylcarbamoyl)-2-hydroxy-5-phenyl-pentyl]-carbamic acid tert-butyl ester

(R)-2-amino-4-methylpentanamide