ethyl 2-(N-acetyl-2'-benzylamino-3',4',6'-trifluorobenzoyl)-3-cyclopropylaminoacrylate

Base Information

Chemical Name:ethyl 2-(N-acetyl-2'-benzylamino-3',4',6'-trifluorobenzoyl)-3-cyclopropylaminoacrylate
CAS No.:123016-65-9
Molecular Formula:C₂₄H₂₃F₃N₂O₄
Molecular Weight:460.453
Hs Code.:

Synonyms:ethyl 2-(N-acetyl-2'-benzylamino-3',4',6'-trifluorobenzoyl)-3-cyclopropylaminoacrylate

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Chemical Property of ethyl 2-(N-acetyl-2'-benzylamino-3',4',6'-trifluorobenzoyl)-3-cyclopropylaminoacrylate

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Technology Process of ethyl 2-(N-acetyl-2'-benzylamino-3',4',6'-trifluorobenzoyl)-3-cyclopropylaminoacrylate

There total 6 articles about ethyl 2-(N-acetyl-2'-benzylamino-3',4',6'-trifluorobenzoyl)-3-cyclopropylaminoacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32890-92-9
2,3,4,6-tetrafluorobenzoic acid

: 123016-65-9
ethyl 2-(N-acetyl-2'-benzylamino-3',4',6'-trifluorobenzoyl)-3-cyclopropylaminoacrylate

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / conc. H₂SO₄ / 68 h / Heating

2: 70 percent / Et₃N / acetonitrile / 2 h / Heating

3: 93 percent / 2N NaOH / methanol / 72 h / Heating

4: 82 percent / Et₃N, 4-(dimethylamino)pyridine

5: oxalyl chloride, DMF / CH₂Cl₂ / 16 h

6: Ac₂O / 3 h / Heating

7: 2-methyl-propan-2-ol / 3.5 h / 45 °C

With dmap; sodium hydroxide; oxalyl dichloride; sulfuric acid; acetic anhydride; triethylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm00107a039

Reference yield:

: 53001-68-6
methyl 2,3,4,6-tetrafluorobenzoate

: 123016-65-9
ethyl 2-(N-acetyl-2'-benzylamino-3',4',6'-trifluorobenzoyl)-3-cyclopropylaminoacrylate

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / Et₃N / acetonitrile / 2 h / Heating

2: 93 percent / 2N NaOH / methanol / 72 h / Heating

3: 82 percent / Et₃N, 4-(dimethylamino)pyridine

4: oxalyl chloride, DMF / CH₂Cl₂ / 16 h

5: Ac₂O / 3 h / Heating

6: 2-methyl-propan-2-ol / 3.5 h / 45 °C

With dmap; sodium hydroxide; oxalyl dichloride; acetic anhydride; triethylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm00107a039

Reference yield:

: 131683-94-8
2-Benzylamino-3,4,6-trifluoro-benzoic acid methyl ester

: 123016-65-9
ethyl 2-(N-acetyl-2'-benzylamino-3',4',6'-trifluorobenzoyl)-3-cyclopropylaminoacrylate

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / 2N NaOH / methanol / 72 h / Heating

2: 82 percent / Et₃N, 4-(dimethylamino)pyridine

3: oxalyl chloride, DMF / CH₂Cl₂ / 16 h

4: Ac₂O / 3 h / Heating

5: 2-methyl-propan-2-ol / 3.5 h / 45 °C

With dmap; sodium hydroxide; oxalyl dichloride; acetic anhydride; triethylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jm00107a039