(Z)-2-benzoyloxy-1-dimethoxyphosphoryl-1-hexene

Base Information

• Chemical Name: (Z)-2-benzoyloxy-1-dimethoxyphosphoryl-1-hexene
• CAS No.: 1104662-03-4
• Molecular Formula: C₁₅H₂₁O₅P
• Molecular Weight: 312.303
• Mol file: 1104662-03-4.mol

Synonyms:(Z)-2-benzoyloxy-1-dimethoxyphosphoryl-1-hexene

Chemical Property of (Z)-2-benzoyloxy-1-dimethoxyphosphoryl-1-hexene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-2-benzoyloxy-1-dimethoxyphosphoryl-1-hexene

There total 1 articles about (Z)-2-benzoyloxy-1-dimethoxyphosphoryl-1-hexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2-oxohexylphosphonic acid dimethyl ester (61728-15-2) + benzoyl chloride (98-88-4) → (Z)-2-benzoyloxy-1-dimethoxyphosphoryl-1-hexene (1104662-03-4)

Guidance literature:

2-oxohexylphosphonic acid dimethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.5h; Inert atmosphere;

benzoyl chloride; In tetrahydrofuran; mineral oil; for 16h; Inert atmosphere;

DOI:10.1002/adsc.201000611

Reference yield: 82.0%

(Z)-2-benzoyloxy-1-dimethoxyphosphoryl-1-hexene (1104662-03-4) → (R)-2-benzoyloxy-1-dimethoxyphosphorylhexane (1104662-12-5) + Hexyl-phosphonsaeure-dimethylester (6172-92-5)

Guidance literature:

With BF₄^(1-)*C₄₄H₆₃IrO₃P₂⁽²⁺⁾; hydrogen; In dichloromethane; at 25 ℃; for 24h; under 3040.2 Torr; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/adsc.201000611

upstream raw materials:

2-oxohexylphosphonic acid dimethyl ester

benzoyl chloride

Downstream raw materials:

(R)-2-benzoyloxy-1-dimethoxyphosphorylhexane

Hexyl-phosphonsaeure-dimethylester

Refernces

• 1、 Vargas, Sergio,Suarez, Andres,Alvarez, Eleuterio,Pizzano, Antonio. "Highly enantioselective hydrogenation of enol ester phosphonates: A versatile procedure for the preparation of chiral β-hydroxyphosphonates". supporting information; experimental part. p. 9856 - 9859. Retrieved 2009/10/02.