(S)-2-Benzyloxycarbonylamino-4-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-butyric acid

Base Information

• Chemical Name: (S)-2-Benzyloxycarbonylamino-4-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-butyric acid
• CAS No.: 152871-77-7
• Molecular Formula: C₁₉H₂₉N₃O₈S
• Molecular Weight: 459.521
• Mol file: 152871-77-7.mol

Synonyms:(S)-2-Benzyloxycarbonylamino-4-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-butyric acid

Chemical Property of (S)-2-Benzyloxycarbonylamino-4-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Benzyloxycarbonylamino-4-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-butyric acid

There total 2 articles about (S)-2-Benzyloxycarbonylamino-4-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(RS)-2-(benzyloxycarbonylamino)-4-(chlorosulfonyl)butanoic acid benzyl ester (69164-71-2) + N-(tert-butyloxycarbonyl)-1,2-ethanediamine hydrochloride (79513-35-2,117083-06-4) → (S)-2-Benzyloxycarbonylamino-4-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-butyric acid (152871-77-7) + (R)-2-Benzyloxycarbonylamino-4-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-butyric acid benzyl ester (152983-19-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Yield given. Title compound not separated from byproducts;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (S)-2-Benzyloxycarbonylamino-4-(2-tert-butoxycarbonylamino-ethylsulfamoyl)-butyric acid (152871-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / 1N NaOH (phenolphthalein) / H₂O; propan-2-ol / 24 h / Ambient temperature

2: DIPEA / dimethylformamide / 1 h / 0 °C

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; isopropyl alcohol;

upstream raw materials:

(RS)-2-(benzyloxycarbonylamino)-4-(chlorosulfonyl)butanoic acid benzyl ester

N-(tert-butyloxycarbonyl)-1,2-ethanediamine hydrochloride

di-tert-butyl dicarbonate