Multi-step reaction with 7 steps
1.1: oxalyl dichloride / dichloromethane / 3 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
3.1: sodium hydroxide; ammonium chloride; ammonium hydroxide; sodium hypochlorite / diethyl ether; tert-butyl methyl ether / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 0 - 20 °C
5.1: triethylamine; triphenylphosphine; bromine / dichloromethane / 2 h / 60 °C
5.2: 32 h / 100 °C
6.1: trifluoroacetic acid / dichloromethane / 20 °C
7.1: N-ethyl-N,N-diisopropylamine; cesium fluoride / butan-1-ol / 40 h / 140 °C / Sealed tube
With
ammonium hydroxide; sodium hypochlorite; oxalyl dichloride; bromine; ammonium chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; cesium fluoride; trifluoroacetic acid; sodium hydroxide;
In
diethyl ether; dichloromethane; tert-butyl methyl ether; ethyl acetate; butan-1-ol;