(S)-2-(1-((5-(3-fluoro-5-hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

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Chemical Name:(S)-2-(1-((5-(3-fluoro-5-hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one
CAS No.:1605328-91-3
Molecular Formula:C₃₃H₃₆FN₇O₃Si
Molecular Weight:625.778
Hs Code.:

(S)-2-(1-((5-(3-fluoro-5-hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Synonyms:(S)-2-(1-((5-(3-fluoro-5-hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

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Chemical Property of (S)-2-(1-((5-(3-fluoro-5-hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

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Technology Process of (S)-2-(1-((5-(3-fluoro-5-hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

There total 14 articles about (S)-2-(1-((5-(3-fluoro-5-hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 871329-82-7
(3-fluoro-5-hydroxyphenyl)boronic acid

: 1605328-90-2
(S)-2-(1-((5-bromo-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

: 1605328-91-3
(S)-2-(1-((5-(3-fluoro-5-hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; water; at 70 ℃; for 2h; Inert atmosphere;

Reference yield:

: 90724-57-5
3-methyl-1H-pyrrole-2-carboxylic acid

: 1605328-91-3
(S)-2-(1-((5-(3-fluoro-5-hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: oxalyl dichloride / dichloromethane / 3 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

3.1: sodium hydroxide; ammonium chloride; ammonium hydroxide; sodium hypochlorite / diethyl ether; tert-butyl methyl ether / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 0 - 20 °C

5.1: triethylamine; triphenylphosphine; bromine / dichloromethane / 2 h / 60 °C

5.2: 32 h / 100 °C

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; cesium fluoride / butan-1-ol / 40 h / 140 °C / Sealed tube

8.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; ammonium hydroxide; sodium hypochlorite; oxalyl dichloride; bromine; sodium carbonate; ammonium chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; cesium fluoride; trifluoroacetic acid; sodium hydroxide; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; tert-butyl methyl ether; water; ethyl acetate; butan-1-ol;

Reference yield:

: 1133931-03-9
C₆H₆ClNO

: 1605328-91-3
(S)-2-(1-((5-(3-fluoro-5-hydroxyphenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

2.1: sodium hydroxide; ammonium chloride; ammonium hydroxide; sodium hypochlorite / diethyl ether; tert-butyl methyl ether / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 0 - 20 °C

4.1: triethylamine; triphenylphosphine; bromine / dichloromethane / 2 h / 60 °C

4.2: 32 h / 100 °C

5.1: trifluoroacetic acid / dichloromethane / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; cesium fluoride / butan-1-ol / 40 h / 140 °C / Sealed tube

7.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; ammonium hydroxide; sodium hypochlorite; bromine; sodium carbonate; ammonium chloride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; cesium fluoride; trifluoroacetic acid; sodium hydroxide; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; tert-butyl methyl ether; water; ethyl acetate; butan-1-ol;