(R)-2-(diMethylaMino)-2-phenylaceticacid

Base Information

• Chemical Name: (R)-2-(diMethylaMino)-2-phenylaceticacid
• CAS No.: 29810-09-1
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Mol file: 29810-09-1.mol

Synonyms:(R)-2-(dimethylamino)-2-phenylacetic acid

Chemical Property of (R)-2-(diMethylaMino)-2-phenylaceticacid

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

(R)-2-(Dimethylamino)-2-phenylaceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(diMethylaMino)-2-phenylaceticacid

There total 5 articles about (R)-2-(diMethylaMino)-2-phenylaceticacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (R)-phenylglycine (875-74-1) → (R)-2-(dimethylamino)-2-phenylacetic acid (29810-09-1)

Guidance literature:

With hydrogenchloride; hydrogen; 5% Pd(II)/C(eggshell); In methanol; water; for 4h; under 1810.07 - 2068.65 Torr;

Reference yield: 46.9%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (R)-(-)-α-methylamino phenylacetic acid (30925-14-5) → (R)-2-(dimethylamino)-2-phenylacetic acid (29810-09-1)

Guidance literature:

With formic acid; for 4h; Heating;

DOI:10.1246/bcsj.66.1430

Reference yield:

2-bromophenylacetic acid (4870-65-9,31302-84-8) → (R)-2-(dimethylamino)-2-phenylacetic acid (29810-09-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 72.1 percent / methanol / 3 h / 20 °C

3: 46.9 percent / aq. formic acid / 4 h / Heating

With formic acid; In methanol;

DOI:10.1246/bcsj.66.1430

upstream raw materials:

formaldehyd

(R)-phenylglycine

(R)-(-)-α-methylamino phenylacetic acid

2-bromophenylacetic acid

Downstream raw materials:

C₄₂H₄₄N₈O₄

methyl (S)-1-((S)-2-(4-(((4-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidine-2-carboxamido)benzyl)(phenyl)amino)methyl)phenylcarbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

C₄₁H₄₇N₇O₃

(R)-1-((S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-2-(dimethylamino)-2-phenylethanone