2-(6-(3,5-difluorophenyl)-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl)propan-2-ol

Base Information

Chemical Name:2-(6-(3,5-difluorophenyl)-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl)propan-2-ol
CAS No.:1310328-39-2
Molecular Formula:C₁₉H₁₆F₂O₃
Molecular Weight:330.331
Hs Code.:

Synonyms:2-(6-(3,5-difluorophenyl)-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl)propan-2-ol

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Chemical Property of 2-(6-(3,5-difluorophenyl)-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl)propan-2-ol

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Technology Process of 2-(6-(3,5-difluorophenyl)-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl)propan-2-ol

There total 6 articles about 2-(6-(3,5-difluorophenyl)-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.6%

: 1155310-14-7
2-(1-hydroxy-1-methyl-ethyl)-5-iodo-2,3-dihydro-benzofuran-6-ol

: 151361-87-4
1-ethynyl-3,5-difluorobenzene

: 1310328-39-2
2-(6-(3,5-difluorophenyl)-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl)propan-2-ol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In 1,4-dioxane; at 85 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.03.022

Reference yield:

: 4806-05-7
2-(1-hydroxy-1-methylethyl)-2,3-dihydrobenzofuran-6-ol

: 1310328-39-2
2-(6-(3,5-difluorophenyl)-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: Iodine monochloride; acetic acid / 3 h

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 1,4-dioxane / 20 h / 85 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Iodine monochloride; acetic acid; triethylamine; In 1,4-dioxane;
DOI:10.1016/j.ejmech.2011.03.022

Reference yield:

: 95-01-2
2,4-Dihydroxybenzaldehyde

: 1310328-39-2
2-(6-(3,5-difluorophenyl)-2,3-dihydrobenzo[1,2-b;5,4-b']difuran-2-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / diethyl ether

2: sodium tetrahydroborate / tetrahydrofuran

3: tetrahydrofuran

4: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 4 h / 0 °C

5: lithium hydroxide / methanol / 20 °C

6: Iodine monochloride; acetic acid / 3 h

7: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 1,4-dioxane / 20 h / 85 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; copper(l) iodide; Iodine monochloride; potassium carbonate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethyl acetate;
DOI:10.1016/j.ejmech.2011.03.022