151361-87-4

Basic information

• Product Name: 1-ETHYNYL-3 5-DIFLUOROBENZENE 97
• Synonyms: 1-ETHYNYL-3 5-DIFLUOROBENZENE 97;1-Ethynyl-3,5-fluorobenzene;Benzene, 1-ethynyl-3,5-difluoro- (9CI);Benzene, 1-ethynyl-3,5-difluoro-;[3,5-Difluorophenyl]ethyne;1-Ethynyl-3,5-difluorobenzene 97%
• CAS NO: 151361-87-4
• Molecular Formula: C₈H₄F₂
• Molecular Weight: 138.1141664
• Product Categories: Alkynyl;Halogenated Hydrocarbons;Organic Building Blocks
• Mol File: 151361-87-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 123-124 °C(lit.)
• Flash Point: 78 °F
• Appearance: /liquid
• Density: 1.163 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.4910(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-ETHYNYL-3 5-DIFLUOROBENZENE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ETHYNYL-3 5-DIFLUOROBENZENE 97(151361-87-4)
• EPA Substance Registry System: 1-ETHYNYL-3 5-DIFLUOROBENZENE 97(151361-87-4)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 151361-87-4(Hazardous Substances Data)

Usage

Uses

1-ethynyl-3,5-difluorobenzene is a useful research chemical.

Chemical Properties

light yellow liquid

Upstream product

• 32085-88-4 3,5-difluorobenzaldehyde 
• 461-96-1 3,5-difluorobromobenzene 
• 1066-54-2 trimethylsilylacetylene 
• 445491-09-8 [2-(3,5-difluorophenyl)ethynyl]trimethylsilane 

Downstream Products

• 151361-94-3 Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-[5-(3,5-difluoro-phenylethynyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl ester 
• 1037183-89-3 2-tert-butoxycarbonylamino-5-[2-(3,5-difluorophenylethynyl)phenyl]imidazole-1-carboxylic acid tert-butyl ester 
• 1037183-90-6 2-tert-butoxycarbonylamino-5-[3-(3,5-difluorophenylethynyl)phenyl]imidazole-1-carboxylic acid tert-butyl ester 
• 1037183-91-7 2-tert-butoxycarbonylamino-5-[4-(3,5-difluorophenylethynyl)phenyl]imidazole-1-carboxylic acid tert-butyl ester 
• 1380597-11-4 1-(1-benzylaziridin-2-yl)-3-(3,5-difluorophenyl)prop-2-yn-1-one 
• 1380597-20-5 3-(1-benzylaziridin-2-yl)-1-(3,5-difluorophenyl)-5-(4-(dimethylamino)phenyl)penta-1,4-diyn-3-ol 
• 1380597-21-6 3-(1-benzylaziridin-2-yl)-1-(3,5-difluorophenyl)-5-(4-methoxyphenyl)penta-1,4-diyn-3-ol 
• 1380597-22-7 3-(1-benzylaziridin-2-yl)-1-(3,5-difluorophenyl)-5-p-tolyl-penta-1,4-diyn-3-ol 
• 1380597-29-4 4-(5-(azidomethyl)-1-benzyl-4-((3,5-difluorophenyl)-ethynyl)-1H-pyrrol-2-yl)-N,Ndimethylaniline 
• 1380597-44-3 4-(1-benzyl-5-(3,5-difluorophenyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)-N,N-dimethylaniline 
• 1380597-45-4 1-benzyl-5-(3,5-difluorophenyl)-2-(4-methoxy-phenyl)-1H-pyrrolo[2,3-c]pyridine 
• 1380597-49-8 1-benzyl-2-(3,5-difluorophenyl)-5-(4-methoxy-phenyl)-1H-pyrrolo[2,3-c]pyridine 
• 1380597-50-1 1-benzyl-2-(3,5-difluorophenyl)-5-p-tolyl-1H-pyrrolo[2,3-c]pyridine 
• 1380597-47-6 C₂₇H₂₀F₂N₂ 

Relevant articles and documents

Anionic sigmatropic-electrocyclic-chugaev cascades: Accessing 12-aryl-5-(methylthiocarbonylthio)tetracenes and a related anthra[2,3-b]thiophene

1,4-Diols resulting from the double addition of ArCCLi (Ar = Ph, substituted phenyl, 2-thienyl) to ortho-C6H4(CHO)2 undergo cascades to tetracenes on simple admixture of LiHDMS, CS2 and MeI. Acene formation proceeds by [3,3]-sigmatropic rearrangement of xanthate anions followed by 6π electrocyclisations. The reactions are terminated by E2 or anionic Chugaev-type eliminations. Structural packing motifs and electronic properties are reported for the tetracenes.

Substituted indoles and their use as integrin antagonists

The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by αvβ3 and αvβ5 integrins, including such conditions as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, D, X, W, a, m, n, i, j, k and v are defined herein.

Palladium-catalyzed coupling of terminal alkynes with 5-(trifluoromethanesulfonyloxy) pyrimidine nucleosides

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