2-<1-(3,4-Dimethoxyphenyl)-3-(hydroxymethyl)-2-naphthyl>-4,4-dimethyl-2-oxazoline

Base Information

Chemical Name:2-<1-(3,4-Dimethoxyphenyl)-3-(hydroxymethyl)-2-naphthyl>-4,4-dimethyl-2-oxazoline
CAS No.:78265-12-0
Molecular Formula:C₂₄H₂₅NO₄
Molecular Weight:391.467
Hs Code.:

Synonyms:2-<1-(3,4-Dimethoxyphenyl)-3-(hydroxymethyl)-2-naphthyl>-4,4-dimethyl-2-oxazoline

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Chemical Property of 2-<1-(3,4-Dimethoxyphenyl)-3-(hydroxymethyl)-2-naphthyl>-4,4-dimethyl-2-oxazoline

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Technology Process of 2-<1-(3,4-Dimethoxyphenyl)-3-(hydroxymethyl)-2-naphthyl>-4,4-dimethyl-2-oxazoline

There total 6 articles about 2-<1-(3,4-Dimethoxyphenyl)-3-(hydroxymethyl)-2-naphthyl>-4,4-dimethyl-2-oxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 883-21-6
1-methoxy-2-naphthoic acid

: 78265-12-0
2-<1-(3,4-Dimethoxyphenyl)-3-(hydroxymethyl)-2-naphthyl>-4,4-dimethyl-2-oxazoline

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / 0.83 h / Heating

2: 99.1 percent / CH₂Cl₂ / 0 - 25 °C

3: 74.7 percent / SOCl₂ / 25 °C

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, 4h, room temp.

5: sec-BuLi, TMEDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) 30 min

6: NaBH₄ / 18 h / Ambient temperature

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In dichloromethane;
DOI:10.1021/jo00332a024

Reference yield:

: 51439-63-5
1-methoxy-2-naphthoyl chloride

: 78265-12-0
2-<1-(3,4-Dimethoxyphenyl)-3-(hydroxymethyl)-2-naphthyl>-4,4-dimethyl-2-oxazoline

Guidance literature:: Multi-step reaction with 5 steps

1: 99.1 percent / CH₂Cl₂ / 0 - 25 °C

2: 74.7 percent / SOCl₂ / 25 °C

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, 4h, room temp.

4: sec-BuLi, TMEDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) 30 min

5: NaBH₄ / 18 h / Ambient temperature

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In dichloromethane;
DOI:10.1021/jo00332a024