(1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-1-((trimethylsilyl)oxy)propan-2-ol

Base Information

• Chemical Name: (1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-1-((trimethylsilyl)oxy)propan-2-ol
• CAS No.: 1547229-17-3
• Molecular Formula: C₁₆H₁₈ClF₃N₂O₂Si
• Molecular Weight: 390.865

Synonyms:(1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-1-((trimethylsilyl)oxy)propan-2-ol

Chemical Property of (1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-1-((trimethylsilyl)oxy)propan-2-ol

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-1-((trimethylsilyl)oxy)propan-2-ol

There total 3 articles about (1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-1-((trimethylsilyl)oxy)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde (861718-85-6) + 4-bromo-5-fluoro-pyrimidine (1003706-87-3) → (1R,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-1-((trimethylsilyl)oxy)propan-2-ol (1474024-63-9) + (1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-1-((trimethylsilyl)oxy)propan-2-ol (1547229-17-3)

Guidance literature:

4-bromo-5-fluoro-pyrimidine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde; In diethyl ether; hexane; at -78 ℃; for 0.5h; Overall yield = 49 %; Overall yield = 77 mg; Inert atmosphere;

Reference yield:

4-bromo-5-fluoro-pyrimidine (1003706-87-3) + 3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanal → (1R,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-1-((trimethylsilyl)oxy)propan-2-ol (1474024-63-9) + (1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-1-((trimethylsilyl)oxy)propan-2-ol (1547229-17-3) + (1R,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)propane-1,2-diol (1474024-64-0)

Guidance literature:

4-bromo-5-fluoro-pyrimidine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanal; In diethyl ether; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jo4019528

Reference yield:

4-bromo-5-fluoro-pyrimidine (1003706-87-3) + 3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanal → (1R,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-2-((trimethylsilyl)oxy)propane-1-ol (1474024-62-8) + (1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-2-((trimethylsilyl)oxy)propan-1-ol (1547229-23-1) + (1R,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-1-((trimethylsilyl)oxy)propan-2-ol (1474024-63-9) + (1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-1-((trimethylsilyl)oxy)propan-2-ol (1547229-17-3)

Guidance literature:

4-bromo-5-fluoro-pyrimidine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

With zinc(II) iodide; In diethyl ether; hexane; at -78 ℃; for 0.333333h; Inert atmosphere;

3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanal; In diethyl ether; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jo4019528

upstream raw materials:

4-bromo-5-fluoro-pyrimidine

3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1547229-17-3 (1S,2S)-3-chloro-2-(2,4-difluorophenyl)-1-(5-fluoropyrimidin-4-yl)-1-((trimethylsilyl)oxy)propan-2-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send