3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde

Base Information

• Chemical Name: 3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde
• CAS No.: 861718-85-6
• Molecular Formula: C₁₂H₁₅ClF₂O₂Si
• Molecular Weight: 292.785
• Mol file: 861718-85-6.mol

Synonyms:3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde

Chemical Property of 3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde

There total 3 articles about 3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile (861718-83-4) → 3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde (861718-85-6)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 - -40 ℃; for 2h;

DOI:10.1021/ol050398+

Reference yield:

2-chloro-1-(2,4-dichlorophenyl)ethanone (51336-94-8) → 3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde (861718-85-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (2S,3S,4R)-2-Ph₂P(O)CH₂-3-OH-4-(2-OH-4,5-F₂-C₆H₂)tetraHpyran; Gd(HMDS)3; propionitrile / 3 h / -40 °C

2: 87 percent / DIBALH / toluene / 2 h / -78 - -40 °C

With tris[N,N-bis(trimethylsilyl)amide]gadolinium(III); (2S,3S,4R)-2-Ph₂P(O)CH₂-3-OH-4-(2-OH-4,5-F₂-C₆H₂)tetraHpyran; diisobutylaluminium hydride; propiononitrile; In toluene;

DOI:10.1021/ol050398+

Reference yield:

3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile → 3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde (861718-85-6) + (R)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanal

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 2h; Overall yield = 351 mg; Inert atmosphere;

DOI:10.1021/jo4019528

upstream raw materials:

(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile

2-chloro-1-(2,4-dichlorophenyl)ethanone

Downstream raw materials:

3-chloro-2-(2,4-difluorophenyl)-2-hydroxypropionaldehyde

(R)-(-)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1,2-diol

(S)-3-chloro-2-(2,4-difluorophenyl)propane-1,2-diol

(2R,3S)-4-chloro-3-(2,4-difluorophenyl)-3-((trimethylsilyl)-oxy)butan-2-ol