(S)-2-<(N-((S)-N-benzyloxycarbonylprolyl)amino)methyl>-N-(p-toluenesulfonyl)pyrrolidine

Base Information

Chemical Name:(S)-2-<(N-((S)-N-benzyloxycarbonylprolyl)amino)methyl>-N-(p-toluenesulfonyl)pyrrolidine
CAS No.:100702-13-4
Molecular Formula:C₂₅H₃₁N₃O₅S
Molecular Weight:485.604
Hs Code.:

Synonyms:(S)-2-<(N-((S)-N-benzyloxycarbonylprolyl)amino)methyl>-N-(p-toluenesulfonyl)pyrrolidine

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Chemical Property of (S)-2-<(N-((S)-N-benzyloxycarbonylprolyl)amino)methyl>-N-(p-toluenesulfonyl)pyrrolidine

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Technology Process of (S)-2-<(N-((S)-N-benzyloxycarbonylprolyl)amino)methyl>-N-(p-toluenesulfonyl)pyrrolidine

There total 6 articles about (S)-2-<(N-((S)-N-benzyloxycarbonylprolyl)amino)methyl>-N-(p-toluenesulfonyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52682-03-8
(S)(-)-N,O-bis(p-toluenesulphonyl)-2-hydroxymethyl pyrrolidine

: 100702-13-4
(S)-2-<(N-((S)-N-benzyloxycarbonylprolyl)amino)methyl>-N-(p-toluenesulfonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / sodium azide / bis-(2-hydroxy-ethyl) ether / 1 h / 100 °C

2: 85 percent / LAH / diethyl ether / 0.25 h

3: Et₃N / CH₂Cl₂ / 1.) cooling, 2 h; 2.) up to RT, 0.5 h

With lithium aluminium tetrahydride; sodium azide; triethylamine; In diethyl ether; dichloromethane; diethylene glycol;
DOI:10.1021/ja00268a051

Reference yield:

: 100702-11-2
(S)-2-(azidomethyl)-N-(p-toluenesulfonyl)pyrrolidine

: 100702-13-4
(S)-2-<(N-((S)-N-benzyloxycarbonylprolyl)amino)methyl>-N-(p-toluenesulfonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / LAH / diethyl ether / 0.25 h

2: Et₃N / CH₂Cl₂ / 1.) cooling, 2 h; 2.) up to RT, 0.5 h

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/ja00268a051

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 100702-13-4
(S)-2-<(N-((S)-N-benzyloxycarbonylprolyl)amino)methyl>-N-(p-toluenesulfonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / pyridine / 12 h

2: 78 percent / sodium azide / bis-(2-hydroxy-ethyl) ether / 1 h / 100 °C

3: 85 percent / LAH / diethyl ether / 0.25 h

4: Et₃N / CH₂Cl₂ / 1.) cooling, 2 h; 2.) up to RT, 0.5 h

With pyridine; lithium aluminium tetrahydride; sodium azide; triethylamine; In diethyl ether; dichloromethane; diethylene glycol;
DOI:10.1021/ja00268a051