Technology Process of 2-tert-butyl-5-(3-methoxy-4-methyl-phenyl)-4,5-dihydro-[1,3]dioxepine
There total 1 articles about 2-tert-butyl-5-(3-methoxy-4-methyl-phenyl)-4,5-dihydro-[1,3]dioxepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; triphenylphosphine;
palladium diacetate;
In
N,N-dimethyl-formamide;
at 80 ℃;
DOI:10.3987/com-98-s(h)4
- Guidance literature:
-
2-tert-butyl-5-(3-methoxy-4-methyl-phenyl)-4,5-dihydro-[1,3]dioxepine;
With
ozone;
In
methanol; dichloromethane;
at -78 ℃;
With
sodium tetrahydroborate;
at 20 ℃;
DOI:10.3987/com-98-s(h)4
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: O3 / CH2Cl2; methanol / -78 °C
1.2: 63 percent / NaBH4 / 20 °C
2.1: PPL / diethyl ether / 39 °C
3.1: Et3N; 4-DMAP / CH2Cl2 / 20 °C
3.2: 65 percent / NaBH4 / dimethylsulfoxide / 60 °C
4.1: 84 percent / nBu3P / pyridine / 20 °C
5.1: 100 percent / MCPBA; KHCO3 / CH2Cl2 / 20 °C
6.1: 82 percent / nBuLi; HMPA / tetrahydrofuran / -78 °C
7.1: 83 percent / Na-Hg; Na2HPO4 / methanol / 20 °C
8.1: 78 percent / L-Selectride / tetrahydrofuran / Heating
With
N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; disodium hydrogenphosphate; n-butyllithium; sodium amalgam; tributylphosphine; L-Selectride; potassium hydrogencarbonate; ozone; triethylamine; 3-chloro-benzenecarboperoxoic acid;
PPL;
In
tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane;
1.1: Ozonolysis / 1.2: Reduction / 2.1: Acetylation / 3.1: Tosylation / 3.2: Reduction / 4.1: Substitution / 5.1: Oxidation / 6.1: Alkylation / 7.1: Reduction / 8.1: Hydrolysis;
DOI:10.3987/com-98-s(h)4
