1-[3-(6-benzyloxy-7-methoxy-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionyl]-2-[4-(tert-butyl-dimethylsilanyloxy)-3-methyl-but-2-enyl]-3-methyl-pyrrolidine-2-carboxylic acid ethyl ester

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Chemical Name:1-[3-(6-benzyloxy-7-methoxy-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionyl]-2-[4-(tert-butyl-dimethylsilanyloxy)-3-methyl-but-2-enyl]-3-methyl-pyrrolidine-2-carboxylic acid ethyl ester
CAS No.:1154527-25-9
Molecular Formula:C₄₃H₆₃N₃O₈Si
Molecular Weight:778.074
Hs Code.:

1-[3-(6-benzyloxy-7-methoxy-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionyl]-2-[4-(tert-butyl-dimethylsilanyloxy)-3-methyl-but-2-enyl]-3-methyl-pyrrolidine-2-carboxylic acid ethyl ester

Synonyms:1-[3-(6-benzyloxy-7-methoxy-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionyl]-2-[4-(tert-butyl-dimethylsilanyloxy)-3-methyl-but-2-enyl]-3-methyl-pyrrolidine-2-carboxylic acid ethyl ester

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Chemical Property of 1-[3-(6-benzyloxy-7-methoxy-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionyl]-2-[4-(tert-butyl-dimethylsilanyloxy)-3-methyl-but-2-enyl]-3-methyl-pyrrolidine-2-carboxylic acid ethyl ester

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Technology Process of 1-[3-(6-benzyloxy-7-methoxy-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionyl]-2-[4-(tert-butyl-dimethylsilanyloxy)-3-methyl-but-2-enyl]-3-methyl-pyrrolidine-2-carboxylic acid ethyl ester

There total 1 articles about 1-[3-(6-benzyloxy-7-methoxy-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionyl]-2-[4-(tert-butyl-dimethylsilanyloxy)-3-methyl-but-2-enyl]-3-methyl-pyrrolidine-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1154527-05-5
C₁₉H₃₇NO₃Si

: 1154527-24-8
3-(6-benzyloxy-7-methoxy-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionic acid

: 1154527-25-9
1-[3-(6-benzyloxy-7-methoxy-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionyl]-2-[4-(tert-butyl-dimethylsilanyloxy)-3-methyl-but-2-enyl]-3-methyl-pyrrolidine-2-carboxylic acid ethyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 96h;
DOI:10.1016/j.tet.2008.08.102

Reference yield:

: 1154527-25-9
1-[3-(6-benzyloxy-7-methoxy-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionyl]-2-[4-(tert-butyl-dimethylsilanyloxy)-3-methyl-but-2-enyl]-3-methyl-pyrrolidine-2-carboxylic acid ethyl ester

: C₃₈H₅₅N₃O₆Si

Guidance literature:: 1-[3-(6-benzyloxy-7-methoxy-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionyl]-2-[4-(tert-butyl-dimethylsilanyloxy)-3-methyl-but-2-enyl]-3-methyl-pyrrolidine-2-carboxylic acid ethyl ester; With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1h;

With water; ammonium chloride; In dichloromethane; at 20 ℃; for 0.75h;

With sodium hydrogencarbonate; In dichloromethane; water;
DOI:10.1016/j.tet.2008.08.102