(4S)-3-[(3R)-3-(p-fluorophenyl)butanoyl]-4-isopropyl-1,3-oxazolan-2-one

Base Information

• Chemical Name: (4S)-3-[(3R)-3-(p-fluorophenyl)butanoyl]-4-isopropyl-1,3-oxazolan-2-one
• CAS No.: 853647-38-8
• Molecular Formula: C₁₆H₂₀FNO₃
• Molecular Weight: 293.338
• Mol file: 853647-38-8.mol

Synonyms:(4S)-3-[(3R)-3-(p-fluorophenyl)butanoyl]-4-isopropyl-1,3-oxazolan-2-one

Chemical Property of (4S)-3-[(3R)-3-(p-fluorophenyl)butanoyl]-4-isopropyl-1,3-oxazolan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S)-3-[(3R)-3-(p-fluorophenyl)butanoyl]-4-isopropyl-1,3-oxazolan-2-one

There total 4 articles about (4S)-3-[(3R)-3-(p-fluorophenyl)butanoyl]-4-isopropyl-1,3-oxazolan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

C15H19FO3 (853647-35-5) + (4S)-4-isopropyl-1,3-oxazolidin-2-one (17016-83-0) → (4S)-3-[(3S)-3-(p-fluorophenyl)butanoyl]-4-isopropyl-1,3-oxazolan-2-one + (4S)-3-[(3R)-3-(p-fluorophenyl)butanoyl]-4-isopropyl-1,3-oxazolan-2-one (853647-38-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1021/jo050019q

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → (4S)-3-[(3R)-3-(p-fluorophenyl)butanoyl]-4-isopropyl-1,3-oxazolan-2-one (853647-38-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / 20 - 35 °C

1.2: 85 percent / tetrahydrofuran / 24 h / Heating

2.1: 98 percent / hydrogen / Pd/C / ethanol / 15 h / 760 Torr

3.1: triethylamine / tetrahydrofuran / -78 - 0 °C

4.1: 26 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; 1.2: Wadsworth-Emmons reaction;

DOI:10.1021/jo050019q

Reference yield:

(E)-3-(4-fluorophenyl)-2-butenoic acid ethyl ester (147471-19-0) → (4S)-3-[(3R)-3-(p-fluorophenyl)butanoyl]-4-isopropyl-1,3-oxazolan-2-one (853647-38-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / hydrogen / Pd/C / ethanol / 15 h / 760 Torr

2: triethylamine / tetrahydrofuran / -78 - 0 °C

3: 26 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane;

DOI:10.1021/jo050019q

upstream raw materials:

C₁₅H₁₉FO₃

(4S)-4-isopropyl-1,3-oxazolidin-2-one

4-fluoro-β-methylbenzenepropanoic acid ethyl ester

1-(4-fluorophenyl)ethanone

Downstream raw materials:

(3R)-3-(p-fluorophenyl)butyl 4-methyl-1-benzenesulfonate

(3R)-1-deuterio-3-(p-fluorophenyl)butane

(3R)-3-(p-fluorophenyl)butan-1-ol