C₃₃H₄₉N₅O₅

Base Information

• Chemical Name: C₃₃H₄₉N₅O₅
• CAS No.: 1190366-70-1
• Molecular Formula: C₃₃H₄₉N₅O₅
• Molecular Weight: 595.783
• Mol file: 1190366-70-1.mol

Synonyms:C₃₃H₄₉N₅O₅

Chemical Property of C₃₃H₄₉N₅O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₄₉N₅O₅

There total 3 articles about C₃₃H₄₉N₅O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tert-butoxyphenyl)propanoic acid (1190366-68-7) + L-arginine methyl ester dihydrochloride (22888-59-1,26340-89-6,78851-84-0,111237-99-1,18598-71-5) → C33H49N5O5 + C33H49N5O5 (1190366-70-1)

Guidance literature:

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In N,N-dimethyl-formamide; at -15 - 20 ℃; for 21h; optical yield given as %de;

DOI:10.1021/mp2003016

Reference yield:

O-tert-butyl-L-tyrosine methyl ester (52616-82-7) → C33H49N5O5 (1190366-70-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 6 h / 20 °C

2: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

3: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol / N,N-dimethyl-formamide / 21 h / -15 - 20 °C

With 4-methyl-morpholine; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/mp2003016

Reference yield:

methyl (S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tertbutoxyphenyl)propanoate (1190366-67-6) → C33H49N5O5 (1190366-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

2: 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol / N,N-dimethyl-formamide / 21 h / -15 - 20 °C

With 4-methyl-morpholine; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/mp2003016

upstream raw materials:

methyl (S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tertbutoxyphenyl)propanoate

(S)-2-[(S)-2-(4-isobutylphenyl)propanamido]-3-(4-tert-butoxyphenyl)propanoic acid

L-arginine methyl ester dihydrochloride

O-tert-butyl-L-tyrosine methyl ester

Downstream raw materials:

C₃₂H₄₇N₅O₅