1-benzyl-5--N'-ethoxy-1H-imidazole-4-carboxamidine

Base Information

• Chemical Name: 1-benzyl-5--N'-ethoxy-1H-imidazole-4-carboxamidine
• CAS No.: 119139-24-1
• Molecular Formula: C₂₀H₂₉N₅O₄
• Molecular Weight: 403.481
• Mol file: 119139-24-1.mol

Synonyms:1-benzyl-5--N'-ethoxy-1H-imidazole-4-carboxamidine

Chemical Property of 1-benzyl-5--N'-ethoxy-1H-imidazole-4-carboxamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-5--N'-ethoxy-1H-imidazole-4-carboxamidine

There total 1 articles about 1-benzyl-5--N'-ethoxy-1H-imidazole-4-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-Benzyl-N'-ethoxy-5-formamido-1H-imidazole-4-carboxamidine (70276-43-6,125661-60-1,125661-61-2) + 1,1-diethoxy-2-iodoethane (51806-20-3) → 1-benzyl-5--N'-ethoxy-1H-imidazole-4-carboxamidine (119139-24-1)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 30 ℃; for 21h;

DOI:10.3987/COM-88-4519

Reference yield: 94.0%

1-benzyl-5--N'-ethoxy-1H-imidazole-4-carboxamidine (119139-24-1) → 1-benzyl-5-(2,2-diethoxyethylamino)-N'-ethoxy-1H-imidazole-4-carboxamidine (119139-25-2)

Guidance literature:

With sodium hydroxide; for 3h; Heating;

DOI:10.3987/COM-88-4519

Reference yield:

1-benzyl-5--N'-ethoxy-1H-imidazole-4-carboxamidine (119139-24-1) → 1-benzyl-5-(2,2-diethoxyethylamino)-1H-imidazole-4-carboxamide (119139-27-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / 1N aq. NaOH / 3 h / Heating

2: HCl, H₂ / Raney Ni W-2 / H₂O / 6 h / 760 Torr / Ambient temperature

3: 1N aq. NaOH / 4 h / Heating

With hydrogenchloride; sodium hydroxide; hydrogen; Raney Ni W-2; In water;

DOI:10.1248/cpb.42.1231

upstream raw materials:

1-Benzyl-N'-ethoxy-5-formamido-1H-imidazole-4-carboxamidine

1,1-diethoxy-2-iodoethane

Downstream raw materials:

1-benzyl-5-(2,2-diethoxyethylamino)-N'-ethoxy-1H-imidazole-4-carboxamidine

3-benzylazepinomycin

1-benzyl-5-(2,2-diethoxyethylamino)-1H-imidazole-4-carboxamide

1-Benzyl-5-(2,2-diethoxy-ethylamino)-1H-imidazole-4-carboxamidine