(3S,4RS)-3-amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester

Base Information

Chemical Name:(3S,4RS)-3-amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester
CAS No.:254751-10-5
Molecular Formula:C₁₅H₁₉F₄NO₄
Molecular Weight:353.314
Hs Code.:

Synonyms:(3S,4RS)-3-amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester

Suppliers and Price of (3S,4RS)-3-amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4RS)-3-amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4RS)-3-amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester

There total 9 articles about (3S,4RS)-3-amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 254750-84-0
tert-butyl (3S)-3-(benzyloxycarbonylamino)-4-hydroxy-5-(2,3,5,6-tetrafluorophenoxy)pentanoate

: 254751-10-5
(3S,4RS)-3-amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1.5h;

Reference yield: 72.0%

: 254751-10-5
(3S,4RS)-3-amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester

Guidance literature:

Reference yield:

: 5545-52-8
Z-D(tBu)-OH

: 254751-10-5
(3S,4RS)-3-amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-hydroxypentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: ClCO₂iBu; NMM / tetrahydrofuran / 0.33 h / -10 °C

1.2: diethyl ether / 0.25 h / 0 °C

2.1: aq. HBr / tetrahydrofuran / 0.5 h / 0 °C

3.1: KF / dimethylformamide / 16 h / 20 °C

4.1: 94 percent / NaBH₄ / ethanol / 1 h / 0 °C

5.1: 93 percent / H₂ / Pd/C / methanol / 4 h / 20 °C / 760 Torr

With 4-methyl-morpholine; potassium fluoride; sodium tetrahydroborate; hydrogen bromide; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.12.106