(1S,2S,3R,4S)-2-<(R)-3-<(2-Methoxyethoxy)methoxy>-1-cyclohexen-1-yl>-3-(methoxymethoxy)-1-<(E)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol

Base Information

• Chemical Name: (1S,2S,3R,4S)-2-<(R)-3-<(2-Methoxyethoxy)methoxy>-1-cyclohexen-1-yl>-3-(methoxymethoxy)-1-<(E)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol
• CAS No.: 162790-73-0
• Molecular Formula: C₃₀H₄₄O₈
• Molecular Weight: 532.675
• Mol file: 162790-73-0.mol

Synonyms:(1S,2S,3R,4S)-2-<(R)-3-<(2-Methoxyethoxy)methoxy>-1-cyclohexen-1-yl>-3-(methoxymethoxy)-1-<(E)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol

Chemical Property of (1S,2S,3R,4S)-2-<(R)-3-<(2-Methoxyethoxy)methoxy>-1-cyclohexen-1-yl>-3-(methoxymethoxy)-1-<(E)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,3R,4S)-2-<(R)-3-<(2-Methoxyethoxy)methoxy>-1-cyclohexen-1-yl>-3-(methoxymethoxy)-1-<(E)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol

There total 1 articles about (1S,2S,3R,4S)-2-<(R)-3-<(2-Methoxyethoxy)methoxy>-1-cyclohexen-1-yl>-3-(methoxymethoxy)-1-<(E)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-<<<3-Bromo-2-cyclohexen-1-yl>oxy>methoxy>-2-methoxyethane + (1S,3R,4S)-3-(Methoxymethoxy)-1-<(E)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanone (162871-68-3) → (1S,2S,3R,4S)-2-<(R)-3-<(2-Methoxyethoxy)methoxy>-1-cyclohexen-1-yl>-3-(methoxymethoxy)-1-<(E)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol (162790-73-0)

Guidance literature:

With tert.-butyl lithium; In tetrahydrofuran; 1.) -78 deg C, 1.5 h, 2.) -78 deg C, 30 min;

DOI:10.1021/jo00109a020

Reference yield:

(1S,2S,3R,4S)-2-<(R)-3-<(2-Methoxyethoxy)methoxy>-1-cyclohexen-1-yl>-3-(methoxymethoxy)-1-<(E)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol (162790-73-0) + methyl iodide (74-88-4) → (1R,4aS,6R,7S,10E,12S,12aR)-2,3,4,4a,6,7,8,9,12,12a-Decahydro-4a-methoxy-1-<(2-methoxyethoxy)methoxy>-6-(methoxymethoxy)-12-(p-methoxyphenoxy)-13,13-dimethyl-7,10-methanobenzocyclodecen-5(1H)-one

Guidance literature:

With 18-crown-6 ether; oxygen; potassium hexamethylsilazane; Yield given. Multistep reaction; 1.) THF, toluene, r.t., 15 min, 2.) 0 deg C to r.t., 1 h;

DOI:10.1021/jo00109a020

Reference yield:

(1S,2S,3R,4S)-2-<(R)-3-<(2-Methoxyethoxy)methoxy>-1-cyclohexen-1-yl>-3-(methoxymethoxy)-1-<(E)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanol (162790-73-0) + methyl iodide (74-88-4) → (1R,4aR,6R,7S,10E,12S,12aR)-2,3,4,4a,6,7,8,9,12,12a-Decahydro-1-<(2-methoxyethoxy)methoxy>-6-(methoxymethoxy)-12-(p-methoxyphenoxy)-4a,13,13-trimethyl-7,10-methanobenzocyclodecen-5(1H)-one + (1R,4aS,6R,7S,10E,12S,12aR)-2,3,4,4a,6,7,8,9,12,12a-Decahydro-4a-methoxy-1-<(2-methoxyethoxy)methoxy>-6-(methoxymethoxy)-12-(p-methoxyphenoxy)-13,13-dimethyl-7,10-methanobenzocyclodecen-5(1H)-one

Guidance literature:

With 18-crown-6 ether; potassium hexamethylsilazane; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, toluene, 0 deg C, 1 h, 2.) 0 deg C, 10 min; r.t., 1 h;

DOI:10.1021/jo00109a020

upstream raw materials:

(1S,3R,4S)-3-(Methoxymethoxy)-1-<(E)-2-(p-methoxyphenoxy)vinyl>-7,7-dimethyl-2-norbornanone