1⁽²⁾H-tetrazole-5-carboxylic acid 3-dimethylcarbamoyl-2-hydroxy-5-methyl-anilide

Base Information

• Chemical Name: 1⁽²⁾H-tetrazole-5-carboxylic acid 3-dimethylcarbamoyl-2-hydroxy-5-methyl-anilide
• CAS No.: 70977-54-7
• Molecular Formula: C₁₂H₁₄N₆O₃
• Molecular Weight: 290.282

Synonyms:1⁽²⁾H-tetrazole-5-carboxylic acid 3-dimethylcarbamoyl-2-hydroxy-5-methyl-anilide

Chemical Property of 1⁽²⁾H-tetrazole-5-carboxylic acid 3-dimethylcarbamoyl-2-hydroxy-5-methyl-anilide

Chemical Property:

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Technology Process of 1⁽²⁾H-tetrazole-5-carboxylic acid 3-dimethylcarbamoyl-2-hydroxy-5-methyl-anilide

There total 6 articles about 1⁽²⁾H-tetrazole-5-carboxylic acid 3-dimethylcarbamoyl-2-hydroxy-5-methyl-anilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

1-benzyl-1H-tetrazole-5-carboxylic acid 3-dimethylcarbamoyl-2-hydroxy-5-methyl-anilide (70978-13-1) → 1(2)H-tetrazole-5-carboxylic acid 3-dimethylcarbamoyl-2-hydroxy-5-methyl-anilide (70977-54-7)

Guidance literature:

With aluminium trichloride; In dichloromethane; for 0.5h; Heating;

DOI:10.1021/jm00154a019

Reference yield:

N,N-dimethyl-2-hydroxy-5-methyl-3-nitrobenzamide (70978-44-8) → 1(2)H-tetrazole-5-carboxylic acid 3-dimethylcarbamoyl-2-hydroxy-5-methyl-anilide (70977-54-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 51 percent / H₂ / 5percent Pd/C / ethanol

2: pyridine / CH₂Cl₂ / 1 h / 20 °C

3: 58 percent / AlCl₃ / CH₂Cl₂ / 0.5 h / Heating

With pyridine; aluminium trichloride; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm00154a019

Reference yield:

2-(dimethylaminocarbonyl)-4-methylphenol (100245-03-2) → 1(2)H-tetrazole-5-carboxylic acid 3-dimethylcarbamoyl-2-hydroxy-5-methyl-anilide (70977-54-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 57 percent / conc. HNO₃, conc. H₂SO₄ / -20 °C

2: 51 percent / H₂ / 5percent Pd/C / ethanol

3: pyridine / CH₂Cl₂ / 1 h / 20 °C

4: 58 percent / AlCl₃ / CH₂Cl₂ / 0.5 h / Heating

With pyridine; aluminium trichloride; sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm00154a019

upstream raw materials:

1-benzyl-1H-tetrazole-5-carboxylic acid 3-dimethylcarbamoyl-2-hydroxy-5-methyl-anilide

3-Amino-2-hydroxy-5-methyl-N,N-dimethyl-benzamid

N,N-dimethyl-2-hydroxy-5-methyl-3-nitrobenzamide

2-(dimethylaminocarbonyl)-4-methylphenol

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