METHYL 3-(1-PYRROLO)THIOPHENE-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL 3-(1-PYRROLO)THIOPHENE-2-CARBOXYLATE
• CAS No.: 74772-16-0
• Molecular Formula: C10H9NO2S
• Molecular Weight: 207.25
• Hs Code.: 2934999090
• Mol file: 74772-16-0.mol

Synonyms:Methyl 3-(1H-pyrrol-1-yl)thiophene-2-carboxylate;Methyl 3-pyrrol-1-ylthiophene-2-carboxylate;3-(1-Pyrrolo)thiophene-2-carboxylic acid methyl eser;

Chemical Property of METHYL 3-(1-PYRROLO)THIOPHENE-2-CARBOXYLATE

Chemical Property:

• Appearance/Colour: white or cream powder
• Vapor Pressure: 6.06E-05mmHg at 25°C
• Melting Point: 63-64 °C
• Refractive Index: 1.613
• Boiling Point: 345.7 °C at 760 mmHg
• Flash Point: 162.9 °C
• PSA: 59.47000
• Density: 1.25 g/cm³
• LogP: 2.32540

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-(1H-Pyrrol-1-yl)-2-thiophenecarboxylate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-(1-PYRROLO)THIOPHENE-2-CARBOXYLATE

There total 2 articles about METHYL 3-(1-PYRROLO)THIOPHENE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + Methyl 3-aminothiophene-2-carboxylate (22288-78-4) → methyl 3-(1H-pyrrol-1-yl)thiophene-2-carboxylate (74772-16-0)

Guidance literature:

In acetic acid; 1) 80 deg C, 30 min, 2) reflux, 1 h;

Reference yield:

Methyl 3-aminothiophene-2-carboxylate (22288-78-4) + 2,5-Dimethoxy-pyrrolidine → methyl 3-(1H-pyrrol-1-yl)thiophene-2-carboxylate (74772-16-0)

Guidance literature:

With acetic acid; for 2h; Heating;

DOI:10.1021/jm950543x

Reference yield: 74.0%

methyl 3-(1H-pyrrol-1-yl)thiophene-2-carboxylate (74772-16-0) → 3-(1H-pyrrol-1-yl)thiophene-2-carboxylic acid (74772-17-1)

Guidance literature:

With sodium hydroxide; for 2.5h; Heating;

upstream raw materials:

cis,trans-2,5-dimethoxytetrahydrofuran

Methyl 3-aminothiophene-2-carboxylate

Downstream raw materials:

3-(1H-pyrrol-1-yl)thiophene-2-carboxylic acid

(3-Pyrrol-1-yl-thiophen-2-yl)-methanol

4-Benzyl-piperazine-1-carboxylic acid (3-pyrrol-1-yl-thiophen-2-yl)-amide

4-(3-Trifluoromethyl-phenyl)-piperazine-1-carboxylic acid (3-pyrrol-1-yl-thiophen-2-yl)-amide