benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate

Base Information

• Chemical Name: benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate
• CAS No.: 1083312-78-0
• Molecular Formula: C₁₉H₁₇NO₆
• Molecular Weight: 355.347
• Mol file: 1083312-78-0.mol

Synonyms:benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate

Chemical Property of benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate

There total 2 articles about benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-2-phenylacetamide (1016950-52-9) + 4-methoxy-2-methylbenzene-1,3-diol (1146148-39-1) → benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate (1083312-78-0)

Guidance literature:

In acetic acid;

Reference yield:

1,3-bis(ethoxymethoxy)-4-methoxy-2-methylbenzene (1083312-67-7) → benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate (1083312-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / water; methanol

2: acetic acid

With hydrogenchloride; In methanol; water; acetic acid;

Reference yield: 99.0%

benzyl 7-hydroxy-6-methoxy-8-methyl-2-oxo-2H-chromen-3-ylcarbamate (1083312-78-0) + acetic anhydride (108-24-7) → 3-(((benzyloxy)carbonyl)amino)-6-methoxy-8-methyl-2-oxo-2H-chromen-7-yl acetate (1308888-98-3)

Guidance literature:

In pyridine; for 12h;

DOI:10.1021/jm200148p

upstream raw materials:

N-(7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yloxy)-8-methyl-2-oxo-2H-chromen-3-yl)-2-phenylacetamide

4-methoxy-2-methylbenzene-1,3-diol

1,3-bis(ethoxymethoxy)-4-methoxy-2-methylbenzene

Downstream raw materials:

benzyl 6-methoxy-7-[(3aR,4S,7R,7aR)-7-methoxy-6,6-dimethyl-2-oxotetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-4-yloxy]-8-methyl-2-oxo-2H-chromen-3-ylcarbamate

benzyl 6-methoxy-8-methyl-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamate

3-(3',6-dimethoxy-[1,1'-biphenyl]-3-ylcarboxamido)-6-methoxy-8-methyl-2-oxo-2H-chromen-7-yl acetate

N-(7-(5,5-dimethylcyclohex-2-enyloxy)-6-methoxy-8-methyl-2-oxochromen-3-yl)-3',6-dimethoxybiphenyl-3-carboxamide