N-[4-[6-tert-butyl-8-(5-fluoro-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide

Base Information

Chemical Name:N-[4-[6-tert-butyl-8-(5-fluoro-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide
CAS No.:1257830-20-8
Molecular Formula:C₂₅H₂₄FN₃O₃S
Molecular Weight:465.548
Hs Code.:

Synonyms:N-[4-[6-tert-butyl-8-(5-fluoro-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide

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Chemical Property of N-[4-[6-tert-butyl-8-(5-fluoro-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide

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Technology Process of N-[4-[6-tert-butyl-8-(5-fluoro-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide

There total 4 articles about N-[4-[6-tert-butyl-8-(5-fluoro-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1257832-04-4
3-(3-bromo-6-tert-butyl-8-quinolyl)-5-fluoro-1H-pyridin-2-one

: 380430-57-9
4-(methylsulfonylamino)phenyl boronic acid

: 1257830-20-8
N-[4-[6-tert-butyl-8-(5-fluoro-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; at 115 ℃; for 2h; microwave irradiation; sealed tube;

Reference yield: 42.0%

: 1257832-02-2
4-tert-butyl-2-(5-fluoro-2-methoxy-3-pyridyl)aniline

: 380430-57-9
4-(methylsulfonylamino)phenyl boronic acid

: 1257830-20-8
N-[4-[6-tert-butyl-8-(5-fluoro-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; dichloromethane; at 115 ℃; for 2h; Inert atmosphere; Microwave irradiation; Sealed tube;
DOI:10.1021/jm401329s

Reference yield:

: 957120-32-0
(5-fluoro-2-methoxypyridin-3-yl)boronic acid

: 1257830-20-8
N-[4-[6-tert-butyl-8-(5-fluoro-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; dichloromethane / 2 h / 115 °C / Inert atmosphere; Microwave irradiation; Sealed tube

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / methanol; dichloromethane / 2 h / 115 °C / Inert atmosphere; Microwave irradiation; Sealed tube

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; dichloromethane;
DOI:10.1021/jm401329s