(S)-N-(3,5-bis(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: (S)-N-(3,5-bis(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide
• CAS No.: 1453069-90-3
• Molecular Formula: C₁₃H₁₃F₆NOS
• Molecular Weight: 345.309

Synonyms:(S)-N-(3,5-bis(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide

Chemical Property of (S)-N-(3,5-bis(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide

Chemical Property:

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Technology Process of (S)-N-(3,5-bis(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide

There total 1 articles about (S)-N-(3,5-bis(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3,5-Bis(trifluoromethyl)benzaldehyde (401-95-6) + (S)-2-methylpropane-2-sulfinamide (343338-28-3) → (S)-N-(3,5-bis(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide (1453069-90-3)

Guidance literature:

With titanium(IV) isopropylate; In dichloromethane; at 0 - 20 ℃; for 20h; Inert atmosphere;

Reference yield: 40.0%

(S)-N-(3,5-bis(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide (1453069-90-3) + vinyl magnesium bromide (1826-67-1) → (S)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)allyl)-2-methylpropane-2-sulfinamide (1453069-91-4) + (S)-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)allyl)-2-methylpropane-2-sulfinamide (1453069-92-5)

Guidance literature:

In tetrahydrofuran; dichloromethane; at -60 - 20 ℃; for 5h;

Reference yield:

(S)-N-(3,5-bis(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide (1453069-90-3) → (E)-N-(3,5-bis(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfonamide

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.orglett.0c02448

upstream raw materials:

3,5-Bis(trifluoromethyl)benzaldehyde

(S)-2-methylpropane-2-sulfinamide

Downstream raw materials:

(S)-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)allyl)-N,2-dimethylpropane-2-sulfinamide

(R)-1-(3,5-bis(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine

(1S,8aS)-7,7-diallyl-N-((R)-1-(3,5-bis(trifluoromethyl)phenyl)allyl)-N-methyl-6-oxo-1-o-tolylhexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide

(S)-N-((S)-1-(3,5-bis(trifluoromethyl)phenyl)allyl)-N,2-dimethylpropane-2-sulfinamide

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