2-{2-[2-nitro-1-(pyridin-2-yl)ethyl]phenyl}acetaldehyde dimethyl acetal

Base Information

Chemical Name:2-{2-[2-nitro-1-(pyridin-2-yl)ethyl]phenyl}acetaldehyde dimethyl acetal
CAS No.:691898-79-0
Molecular Formula:C₁₇H₂₀N₂O₄
Molecular Weight:316.357
Hs Code.:

Synonyms:2-{2-[2-nitro-1-(pyridin-2-yl)ethyl]phenyl}acetaldehyde dimethyl acetal

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Chemical Property of 2-{2-[2-nitro-1-(pyridin-2-yl)ethyl]phenyl}acetaldehyde dimethyl acetal

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Technology Process of 2-{2-[2-nitro-1-(pyridin-2-yl)ethyl]phenyl}acetaldehyde dimethyl acetal

There total 3 articles about 2-{2-[2-nitro-1-(pyridin-2-yl)ethyl]phenyl}acetaldehyde dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: (E)-2-[2-(2-nitrovinyl)phenyl]acetaldehyde dimethyl acetal

: 109-04-6
2-bromo-pyridine

: 691898-79-0
2-{2-[2-nitro-1-(pyridin-2-yl)ethyl]phenyl}acetaldehyde dimethyl acetal

Guidance literature:: 2-bromo-pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

(E)-2-[2-(2-nitrovinyl)phenyl]acetaldehyde dimethyl acetal; In tetrahydrofuran; hexane; at -78 ℃; for 7.5h;
DOI:10.1016/j.bmc.2003.12.036

Reference yield:

: 691898-09-6
2-[2-(1-hydroxy-2-nitroethyl)phenyl]acetaldehyde dimethyl acetal

: 691898-79-0
2-{2-[2-nitro-1-(pyridin-2-yl)ethyl]phenyl}acetaldehyde dimethyl acetal

Guidance literature:: Multi-step reaction with 2 steps

1.1: 79 percent / methanesulfonyl chloride; Et₃N / CH₂Cl₂ / 8 h / 0 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.2: 47 percent / tetrahydrofuran; hexane / 7.5 h / -78 °C

With n-butyllithium; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.bmc.2003.12.036

Reference yield:

: 112396-12-0
Homophthalaldehyd-monodimethylacetal

: 691898-79-0
2-{2-[2-nitro-1-(pyridin-2-yl)ethyl]phenyl}acetaldehyde dimethyl acetal

Guidance literature:: Multi-step reaction with 3 steps

1.1: 79 percent / KOH / methanol; H₂O / 7 h / 0 °C

2.1: 79 percent / methanesulfonyl chloride; Et₃N / CH₂Cl₂ / 8 h / 0 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

3.2: 47 percent / tetrahydrofuran; hexane / 7.5 h / -78 °C

With potassium hydroxide; n-butyllithium; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; 1.1: Henry reaction;
DOI:10.1016/j.bmc.2003.12.036