3-{[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid tert-butyl ester

Base Information

Chemical Name:3-{[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid tert-butyl ester
CAS No.:1455087-31-6
Molecular Formula:C₂₂H₁₇F₂N₃O₅
Molecular Weight:441.391
Hs Code.:

Synonyms:3-{[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid tert-butyl ester

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Chemical Property of 3-{[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid tert-butyl ester

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Technology Process of 3-{[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid tert-butyl ester

There total 8 articles about 3-{[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455091-72-1
3-{[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid tert-butyl ester

: 1455087-31-6
3-{[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid tert-butyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 75235-66-4
cyano-dimethylacetic acid tert-butyl ester

: 1455087-31-6
3-{[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / methanol / 20 °C

2: ethanol / 1 h / 140 °C / Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 20 °C

With hydrogen; trifluoroacetic acid; In methanol; ethanol; dichloromethane;

Reference yield:

: 260561-85-1
4-bromo-2-(bromomethyl)benzoic acid ethyl ester

: 1455087-31-6
3-{[1-cyano-7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carbonyl]amino}-2,2-dimethyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 20 °C

2: copper(l) chloride; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate / 1-methyl-pyrrolidin-2-one / 24 h / 130 °C

3: potassium 2-methylbutan-2-olate / tetrahydrofuran; toluene / 0.5 h / 20 °C / Cooling with ice

4: N-Bromosuccinimide / acetonitrile / 2 h / Cooling with ice

5: 1-methyl-pyrrolidin-2-one / 1 h / 150 °C

6: ethanol / 1 h / 140 °C / Microwave irradiation

7: trifluoroacetic acid / dichloromethane / 20 °C

With N-Bromosuccinimide; 2,2,6,6-tetramethylheptane-3,5-dione; potassium 2-methylbutan-2-olate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; copper(l) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;