2-(1H-indol-3-ylsulfanyl)aniline

Base Information

• Chemical Name: 2-(1H-indol-3-ylsulfanyl)aniline
• CAS No.: 32884-72-3
• Molecular Formula: C₁₄H₁₂N₂S
• Molecular Weight: 240.329
• DSSTox Substance ID: DTXSID901327909
• Nikkaji Number: J3.065.336J
• ChEMBL ID: CHEMBL1305415
• Mol file: 32884-72-3.mol

Synonyms:2-(1H-indol-3-ylsulfanyl)aniline;32884-72-3;2-((1H-indol-3-yl)thio)aniline;2-(1H-Indol-3-ylsulfanyl)-phenylamine;MLS001167954;CHEMBL1305415;DTXSID901327909;HMS2956N07;STL487774;AKOS000267253;SMR000641170;SR-01000014898;SR-01000014898-1;F1754-0012

Chemical Property of 2-(1H-indol-3-ylsulfanyl)aniline

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 240.07211956
• Heavy Atom Count: 17
• Complexity: 259

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CN2)SC3=CC=CC=C3N

Technology Process of 2-(1H-indol-3-ylsulfanyl)aniline

There total 10 articles about 2-(1H-indol-3-ylsulfanyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

indole (120-72-9) + 2-amino-benzenethiol (137-07-5) → indol-3-yl o-aminophenyl sulphide (32884-72-3)

Guidance literature:

With sodium hydroxide; In dimethyl sulfoxide; at 70 ℃; for 6h;

DOI:10.1039/c4ra05206d

Reference yield: 94.0%

indol-3-yl 2-nitrophenyl sulphide (72496-78-7) → indol-3-yl o-aminophenyl sulphide (32884-72-3)

Guidance literature:

With hydrazine hydrate; palladium on activated charcoal; In ethanol; for 3h; Heating;

Reference yield: 88.0%

indole (120-72-9) + 2-Aminophenyl disulfide (1141-88-4) → indol-3-yl o-aminophenyl sulphide (32884-72-3)

Guidance literature:

With iodine; dimethyl sulfoxide; In carbonic acid dimethyl ester; at 40 ℃; for 10h;

DOI:10.1039/c2gc35337g

upstream raw materials:

indol-3-yl 2-nitrophenyl sulphide

bis(2-nitrophenyl)disulfide

2-nitrobenzenesulfenyl chloride

indole