RO9021

Base Information

• Chemical Name: RO9021
• CAS No.: 1446790-62-0
• Molecular Formula: C₁₈H₂₅N₇O
• Molecular Weight: 355.443
• Mol file: 1446790-62-0.mol

Synonyms:6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

Chemical Property of RO9021

Chemical Property:

• Solubility.: Soluble in DMSO

Purity/Quality:

97% ^*data from raw suppliers

RO0921 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of RO9021

There total 7 articles about RO9021 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

6-chloro-4-(5,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide (1446791-48-5) + tert-butyl (1S,2R)-2-(6-carbamoyl-5-(4,6-dimethylpyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate (1446792-19-3) → 6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide (1446790-62-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

Reference yield: 49.0%

6-chloro-4-(6-isopropylpyridin-2-ylamino)pyridazine-3-carboxamide (1446791-41-8) + tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate (365996-30-1) → 6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide (1446790-62-0)

Guidance literature:

6-chloro-4-(6-isopropylpyridin-2-ylamino)pyridazine-3-carboxamide; tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 72h;

With trifluoroacetic acid; In dichloromethane; for 18h;

DOI:10.1021/jm401982j

Reference yield:

4,6-Dichloro-pyridazine-3-carboxylic acid ethyl ester (679406-03-2) → 6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide (1446790-62-0)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile / 20 h / 140 °C / Sealed tube

2: ammonia / methanol / 18 h / 50 °C

3: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With ammonia; trifluoroacetic acid; In methanol; dichloromethane; acetonitrile;

upstream raw materials:

4,6-Dichloro-pyridazine-3-carboxylic acid ethyl ester

2-amino-5,6-dimethylpyridine

ethyl 6-chloro-4-(5,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxylate

6-chloro-4-(5,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxamide