5,6-Dimethylpyridin-2-amine

Base Information

• Chemical Name: 5,6-Dimethylpyridin-2-amine
• CAS No.: 57963-08-3
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 29339990
• European Community (EC) Number: 814-462-3
• NSC Number: 95996
• DSSTox Substance ID: DTXSID90973537
• Nikkaji Number: J1.385.268E
• ChEMBL ID: CHEMBL59592
• Mol file: 57963-08-3.mol

Synonyms:5,6-dimethylpyridin-2-amine;57963-08-3;2-Amino-5,6-dimethylpyridine;6-Amino-2,3-dimethylpyridine;5,6-Dimethyl-pyridin-2-ylamine;CHEMBL59592;MFCD06200777;2-Pyridinamine, 5,6-dimethyl-;5,6-dimethyl-2-Pyridinamine;NSC95996;(+)-Lysergide-d3;NCIOpen2_001770;SCHEMBL1021601;DTXSID90973537;UZAOIPZZPZCFES-UHFFFAOYSA-N;5,6-Dimethylpyridin-2(1H)-imine;AMY31022;BBL102792;BDBM50091802;NSC-95996;STL556599;AKOS006282990;AB23050;PS-5011;2-amino-5,6-dimethylpyridine, AldrichCPR;A8244;CS-0153596;FT-0661772;C75720

Chemical Property of 5,6-Dimethylpyridin-2-amine

Chemical Property:

• Appearance/Colour: Light Yellow Low-Melting Solid
• Vapor Pressure: 0.0611mmHg at 25°C
• Refractive Index: 1.564
• Boiling Point: 231.8 °C at 760 mmHg
• Flash Point: 116.9 °C
• PSA: 38.91000
• Density: 1.039 g/cm³
• LogP: 1.86180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Chloroform, Dichloromethane
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 92.9

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-5,6-dimethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-37/39-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=C(C=C1)N)C

Technology Process of 5,6-Dimethylpyridin-2-amine

There total 8 articles about 5,6-Dimethylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

5-bromo-6-methyl-pyridin-2-ylamine (42753-71-9) + Trimethylboroxine (823-96-1) → 2-amino-5,6-dimethylpyridine (57963-08-3)

Guidance literature:

With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; for 3h; Heating / reflux;

Reference yield:

ethyl 1-((5,6-dimethylimidazo[1,2-a]pyridin-2-yl)methyl)-1H-pyrazole-4-carboxylate → 1-((5,6-dimethylimidazo[1,2-a]pyridin-2-yl)methyl)-1H-pyrazole-4-carboxylic acid + 2-amino-5,6-dimethylpyridine (57963-08-3)

Guidance literature:

With hydrogenchloride; lithium hydroxide;

Reference yield:

2,3-dimethylpyridine 1-oxide (22710-07-2,166521-76-2) → 2-amino-5,6-dimethylpyridine (57963-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / Heating

2: conc. HCl

With hydrogenchloride; In dichloromethane; 1: Substitution / 2: Hydrolysis;

DOI:10.1016/S0960-894X(00)00389-9

upstream raw materials:

2,3-Lutidine

2,3-dimethylpyridine 1-oxide

5-bromo-6-methyl-pyridin-2-ylamine

Trimethylboroxine

Downstream raw materials:

2-amino-3-bromo-5,6-dimethylpyridine

C₂₀H₁₇N₃O₂S

6-((1R,2S)-2-amino-cyclohexylamino)-4-(5,6-dimethyl-pyridin-2-ylamino)-pyridazine-3-carboxylic acid amide

tert-butyl (1S,2R)-2-(6-carbamoyl-5-(4,6-dimethylpyridin-2-ylamino)pyridazin-3-ylamino)cyclohexylcarbamate