N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-fluoro-benzamide

Base Information

• Chemical Name: N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-fluoro-benzamide
• CAS No.: 1035269-22-7
• Molecular Formula: C₂₀H₂₀FN₃O₃
• Molecular Weight: 369.396
• Mol file: 1035269-22-7.mol

Synonyms:N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-fluoro-benzamide

Chemical Property of N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-fluoro-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-fluoro-benzamide

There total 3 articles about N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-fluoro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.11%

3-(3,5-dimethoxyphenylethyl)-1H-pyrazol-5-amine (1000895-53-3) + 4-fluorobenzoic acid ethyl ester (451-46-7) → N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-fluoro-benzamide (1035269-22-7)

Guidance literature:

With trimethylaluminum; In toluene; at 20 ℃; for 18h; Product distribution / selectivity;

Reference yield: 14.06%

3-(3,5-dimethoxyphenylethyl)-1H-pyrazol-5-amine (1000895-53-3) + methyl 4-flurobenzoate (403-33-8) → N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-fluoro-benzamide (1035269-22-7)

Guidance literature:

With trimethylaluminum; In toluene; at 20 ℃; for 38h; Product distribution / selectivity;

Reference yield: 3.0%

3-(3,5-dimethoxyphenylethyl)-1H-pyrazol-5-amine (1000895-53-3) + 4-Fluorobenzoic acid (456-22-4) → N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-fluoro-benzamide (1035269-22-7)

Guidance literature:

4-Fluorobenzoic acid; With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 1h;

3-(3,5-dimethoxyphenylethyl)-1H-pyrazol-5-amine; In dichloromethane; at 0 - 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

upstream raw materials:

3-(3,5-dimethoxyphenylethyl)-1H-pyrazol-5-amine

4-fluorobenzoic acid ethyl ester

4-Fluorobenzoic acid

methyl 4-flurobenzoate

Downstream raw materials:

N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,3-dimethylpiperazin-1-yl)benzamide

N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-[4-(1-hydroxypropan-2-yl)piperazin-1-yl]benzamide