(2R,5R)-4,4-diethyl 2-methyl 1-benzoyl-5-(4-bromophenyl)-3-(2,2-diphenylvinylidene)-2-methylpyrrolidine-2,4,4-tricarboxylate

Base Information

Chemical Name:(2R,5R)-4,4-diethyl 2-methyl 1-benzoyl-5-(4-bromophenyl)-3-(2,2-diphenylvinylidene)-2-methylpyrrolidine-2,4,4-tricarboxylate
CAS No.:1309923-14-5
Molecular Formula:C₄₀H₃₆BrNO₇
Molecular Weight:722.632
Hs Code.:

Synonyms:(2R,5R)-4,4-diethyl 2-methyl 1-benzoyl-5-(4-bromophenyl)-3-(2,2-diphenylvinylidene)-2-methylpyrrolidine-2,4,4-tricarboxylate

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Chemical Property of (2R,5R)-4,4-diethyl 2-methyl 1-benzoyl-5-(4-bromophenyl)-3-(2,2-diphenylvinylidene)-2-methylpyrrolidine-2,4,4-tricarboxylate

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Technology Process of (2R,5R)-4,4-diethyl 2-methyl 1-benzoyl-5-(4-bromophenyl)-3-(2,2-diphenylvinylidene)-2-methylpyrrolidine-2,4,4-tricarboxylate

There total 3 articles about (2R,5R)-4,4-diethyl 2-methyl 1-benzoyl-5-(4-bromophenyl)-3-(2,2-diphenylvinylidene)-2-methylpyrrolidine-2,4,4-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1309923-12-3
(2R,5R)-4,4-diethyl 2-methyl 5-(4-bromophenyl)-3-(2,2-diphenylvinylidene)-2-methylpyrrolidine-2,4,4-tricarboxylate

: 98-88-4
benzoyl chloride

: 1309923-14-5
(2R,5R)-4,4-diethyl 2-methyl 1-benzoyl-5-(4-bromophenyl)-3-(2,2-diphenylvinylidene)-2-methylpyrrolidine-2,4,4-tricarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1039/c1ob05291h

Reference yield:

: 1240422-91-6
methyl 2-(p-bromobenzylideneamino)propionate

: 1309923-14-5
(2R,5R)-4,4-diethyl 2-methyl 1-benzoyl-5-(4-bromophenyl)-3-(2,2-diphenylvinylidene)-2-methylpyrrolidine-2,4,4-tricarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: (S)-TF-Biphamphos; silver(I) acetate; potassium carbonate / dichloromethane / 24 h / 0 °C / Inert atmosphere

2: triethylamine / dichloromethane / 20 °C

With (S)-TF-Biphamphos; silver(I) acetate; potassium carbonate; triethylamine; In dichloromethane;
DOI:10.1039/c1ob05291h

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1309923-14-5
(2R,5R)-4,4-diethyl 2-methyl 1-benzoyl-5-(4-bromophenyl)-3-(2,2-diphenylvinylidene)-2-methylpyrrolidine-2,4,4-tricarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium sulfate; triethylamine / dichloromethane / 1 h / 20 °C

1.2: 20 °C

2.1: (S)-TF-Biphamphos; silver(I) acetate; potassium carbonate / dichloromethane / 24 h / 0 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 20 °C

With (S)-TF-Biphamphos; silver(I) acetate; magnesium sulfate; potassium carbonate; triethylamine; In dichloromethane;
DOI:10.1039/c1ob05291h