Technology Process of (2S,3S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-3-hydroxypropanoic acid
There total 11 articles about (2S,3S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-3-hydroxypropanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2S,3S)-2-benzylamino-3-cyclohexyl-3-hydroxypropanoic acid;
With
20 % Pd(OH)2/C; hydrogen; sodium hydroxide;
In
methanol;
for 8h;
di-tert-butyl dicarbonate;
With
sodium hydroxide;
In
methanol;
Inert atmosphere;
With
potassium hydrogensulfate;
In
water;
pH=3;
DOI:10.1016/j.bmc.2011.05.022
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sulfuric acid / methanol
2: diisobutylaluminium hydride / tetrahydrofuran
3: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; Cumene hydroperoxide / dichloromethane / Molecular sieve
4: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide
5: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; acetonitrile
6: sodium hydroxide / water
7: 20 % Pd(OH)2/C; hydrogen / methanol
8: sodium hydroxide
With
titanium(IV) isopropylate; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diethyl (2R,3R)-tartrate; Cumene hydroperoxide; sulfuric acid; 20 % Pd(OH)2/C; hydrogen; sulfur trioxide pyridine complex; diisobutylaluminium hydride; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
3: Sharpless epoxidation;
DOI:10.1016/j.bmcl.2010.12.109
- Guidance literature:
-
Multi-step reaction with 7 steps
1: diisobutylaluminium hydride / tetrahydrofuran
2: titanium(IV) isopropylate; diethyl (2R,3R)-tartrate; Cumene hydroperoxide / dichloromethane / Molecular sieve
3: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide
4: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; acetonitrile
5: sodium hydroxide / water
6: 20 % Pd(OH)2/C; hydrogen / methanol
7: sodium hydroxide
With
titanium(IV) isopropylate; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; diethyl (2R,3R)-tartrate; Cumene hydroperoxide; 20 % Pd(OH)2/C; hydrogen; sulfur trioxide pyridine complex; diisobutylaluminium hydride; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
2: Sharpless epoxidation;
DOI:10.1016/j.bmcl.2010.12.109
