(S)-N-(2-(3-(cyclopentyloxy)-4-fluorophenyl)-2-(trimethylsilyloxy)butyl)-3-(methoxymethoxy)propane-1-sulfonamide

Base Information

• Chemical Name: (S)-N-(2-(3-(cyclopentyloxy)-4-fluorophenyl)-2-(trimethylsilyloxy)butyl)-3-(methoxymethoxy)propane-1-sulfonamide
• CAS No.: 1198224-00-8
• Molecular Formula: C₂₃H₄₀FNO₆SSi
• Molecular Weight: 505.724
• Mol file: 1198224-00-8.mol

Synonyms:(S)-N-(2-(3-(cyclopentyloxy)-4-fluorophenyl)-2-(trimethylsilyloxy)butyl)-3-(methoxymethoxy)propane-1-sulfonamide

Chemical Property of (S)-N-(2-(3-(cyclopentyloxy)-4-fluorophenyl)-2-(trimethylsilyloxy)butyl)-3-(methoxymethoxy)propane-1-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(2-(3-(cyclopentyloxy)-4-fluorophenyl)-2-(trimethylsilyloxy)butyl)-3-(methoxymethoxy)propane-1-sulfonamide

There total 15 articles about (S)-N-(2-(3-(cyclopentyloxy)-4-fluorophenyl)-2-(trimethylsilyloxy)butyl)-3-(methoxymethoxy)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H36FNO5SSi (1198224-02-0) + chloromethyl methyl ether (107-30-2) → (S)-N-(2-(3-(cyclopentyloxy)-4-fluorophenyl)-2-(trimethylsilyloxy)butyl)-3-(methoxymethoxy)propane-1-sulfonamide (1198224-00-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

4-fluoro-3-hydroxybenzoic acid (51446-31-2) → (S)-N-(2-(3-(cyclopentyloxy)-4-fluorophenyl)-2-(trimethylsilyloxy)butyl)-3-(methoxymethoxy)propane-1-sulfonamide (1198224-00-8)

Guidance literature:

Multi-step reaction with 15 steps

1.1: sulfuric acid / 4 h / 105 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 125 °C

3.1: water; sodium hydroxide / ethanol / 3 h / 55 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.08 h / 20 °C

4.2: 13 h / 20 °C

5.1: tetrahydrofuran / 2.5 h / 0 °C

6.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

6.2: 3 h / -78 - 20 °C

7.1: potassium osmate(VI); water; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III) / tert-butyl alcohol / 5 h / 0 °C

8.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

9.1: sodium azide / N,N-dimethyl-formamide / 15 h / 75 °C

10.1: 2,6-dimethylpyridine / 1 h / 20 °C

11.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

12.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

13.1: sodium iodide / N,N-dimethyl-formamide / 8 h / 80 °C

14.1: methylamine / methanol / 1 h / 20 °C

15.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With 2,6-dimethylpyridine; potassium osmate(VI); sodium azide; sulfuric acid; water; hydrogen; sodium hexamethyldisilazane; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; N-ethyl-N,N-diisopropylamine; methylamine; sodium iodide; sodium hydroxide; potassium hexacyanoferrate(III); palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

ethyl 3-hydroxy-4-fluorobenzoate (351317-28-7) → (S)-N-(2-(3-(cyclopentyloxy)-4-fluorophenyl)-2-(trimethylsilyloxy)butyl)-3-(methoxymethoxy)propane-1-sulfonamide (1198224-00-8)

Guidance literature:

Multi-step reaction with 14 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 125 °C

2.1: water; sodium hydroxide / ethanol / 3 h / 55 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 13 h / 20 °C

4.1: tetrahydrofuran / 2.5 h / 0 °C

5.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

5.2: 3 h / -78 - 20 °C

6.1: potassium osmate(VI); water; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III) / tert-butyl alcohol / 5 h / 0 °C

7.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

8.1: sodium azide / N,N-dimethyl-formamide / 15 h / 75 °C

9.1: 2,6-dimethylpyridine / 1 h / 20 °C

10.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

11.1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C

12.1: sodium iodide / N,N-dimethyl-formamide / 8 h / 80 °C

13.1: methylamine / methanol / 1 h / 20 °C

14.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With 2,6-dimethylpyridine; potassium osmate(VI); sodium azide; water; hydrogen; sodium hexamethyldisilazane; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; N-ethyl-N,N-diisopropylamine; methylamine; sodium iodide; sodium hydroxide; potassium hexacyanoferrate(III); palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

upstream raw materials:

C₂₁H₃₆FNO₅SSi

chloromethyl methyl ether

4-fluoro-3-hydroxybenzoic acid

ethyl 3-hydroxy-4-fluorobenzoate