[1-(N-tert-butyloxycarbonyl)amino]-N-4-chlorophenylacetamide

Base Information

• Chemical Name: [1-(N-tert-butyloxycarbonyl)amino]-N-4-chlorophenylacetamide
• CAS No.: 107609-81-4
• Molecular Formula: C₁₃H₁₇ClN₂O₃
• Molecular Weight: 284.743
• Mol file: 107609-81-4.mol

Synonyms:[1-(N-tert-butyloxycarbonyl)amino]-N-4-chlorophenylacetamide

Chemical Property of [1-(N-tert-butyloxycarbonyl)amino]-N-4-chlorophenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(N-tert-butyloxycarbonyl)amino]-N-4-chlorophenylacetamide

There total 3 articles about [1-(N-tert-butyloxycarbonyl)amino]-N-4-chlorophenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

BOC-glycine (4530-20-5) + 4-chloro-aniline (106-47-8) → [1-(N-tert-butyloxycarbonyl)amino]-N-4-chlorophenylacetamide (107609-81-4)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

Reference yield:

BOC-glycine (4530-20-5) → [1-(N-tert-butyloxycarbonyl)amino]-N-4-chlorophenylacetamide (107609-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / tetrahydrofuran / 0.08 h / -15 °C

2: N-methylmorpholine / tetrahydrofuran / 18 h / Ambient temperature

With 4-methyl-morpholine; In tetrahydrofuran;

DOI:10.1016/0223-5234(96)85171-3

Reference yield:

N-(t-butoxycarbonyl)glycyl i-butyl carbonate (66866-43-1) + 4-chloro-aniline (106-47-8) → [1-(N-tert-butyloxycarbonyl)amino]-N-4-chlorophenylacetamide (107609-81-4)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; for 18h; Yield given; Ambient temperature;

DOI:10.1016/0223-5234(96)85171-3

upstream raw materials:

N-(t-butoxycarbonyl)glycyl i-butyl carbonate

4-chloro-aniline

BOC-glycine

Downstream raw materials:

2-amino-N-(4-chloro-phenyl)-acetamide hydrochloride

2-amino-N-(4-chlorophenyl)acetamide