Technology Process of 6α-ethyl-3α-hydroxy-7-keto-24-nor-5β-cholan-23-oic acid
There total 1 articles about 6α-ethyl-3α-hydroxy-7-keto-24-nor-5β-cholan-23-oic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 5%-palladium/activated carbon; hydrogen / methanol; tetrahydrofuran / 8 h / 20 °C / Inert atmosphere
2.1: sodium hydroxide / methanol; water / Reflux
3.1: perchloric acid / water / 6 h / 47 - 50 °C
3.2: 0.33 h / 40 °C
4.1: trifluoroacetic anhydride; sodium nitrite / trifluoroacetic acid / 3 h / 0 - 40 °C
5.1: potassium hydroxide / methanol; water / 48 h / Reflux
With
perchloric acid; 5%-palladium/activated carbon; hydrogen; trifluoroacetic anhydride; potassium hydroxide; sodium hydroxide; sodium nitrite;
In
tetrahydrofuran; methanol; water; trifluoroacetic acid;
3.1: |Fischer-Speier Esterification / 4.1: |Beckmann Rearrangement;
DOI:10.1021/jm401873d
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / 12 h / 60 °C / Large scale
2.1: 1H-imidazole; triethylamine / dichloromethane / 16 h / 5 - 20 °C / Large scale
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.5 h / 5 - 15 °C / Inert atmosphere; Large scale
3.2: 12 h / Large scale
With
1H-imidazole; lithium aluminium tetrahydride; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / 12 h / 60 °C / Large scale
2.1: 1H-imidazole; triethylamine / dichloromethane / 16 h / 5 - 20 °C / Large scale
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.5 h / 5 - 15 °C / Inert atmosphere; Large scale
3.2: 12 h / Large scale
4.1: 1H-imidazole / dichloromethane / 5 h / 5 - 15 °C / Large scale
5.1: potassium carbonate / ethanol / 14 h / 15 °C / Large scale
With
1H-imidazole; lithium aluminium tetrahydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane;
