5-(3-Chlorophenyl)thiophene-2-carboxylic acid

Base Information

Chemical Name:5-(3-Chlorophenyl)thiophene-2-carboxylic acid
CAS No.:893733-15-8
Molecular Formula:C₁₁H₇ClO₂S
Molecular Weight:238.694
Hs Code.:
European Community (EC) Number:972-366-8

Synonyms:5-(3-chlorophenyl)thiophene-2-carboxylic acid;893733-15-8;SCHEMBL3754699;AKOS002676530;CS-0249782;5-(3-chlorophenyl)thiophene-2-carboxylicacid;EN300-45181;G21687;Z361925608

Suppliers and Price of 5-(3-Chlorophenyl)thiophene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 5-(3-Chlorophenyl)thiophene-2-carboxylic acid

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:237.9855283
Heavy Atom Count:15
Complexity:247

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC(=C1)Cl)C2=CC=C(S2)C(=O)O

Technology Process of 5-(3-Chlorophenyl)thiophene-2-carboxylic acid

There total 4 articles about 5-(3-Chlorophenyl)thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1024448-92-7
C₁₂H₉ClO₂S

: 893733-15-8
C₁₁H₇ClO₂S

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; for 24h; Inert atmosphere;
DOI:10.1002/cmdc.201000475

Reference yield:

: 62224-19-5
5-bromo-2-thiophenecarboxylic acid methyl ester

: 893733-15-8
C₁₁H₇ClO₂S

Guidance literature:: Multi-step reaction with 2 steps

1: Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 100 °C

2: aq. LiOH / tetrahydrofuran

With lithium hydroxide; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.04.022

Reference yield:

: 63503-60-6
3-chlorophenylboronic acid

: 893733-15-8
C₁₁H₇ClO₂S

Guidance literature:: Multi-step reaction with 2 steps

1: Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 100 °C

2: aq. LiOH / tetrahydrofuran

With lithium hydroxide; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.04.022