62224-19-5

Basic information

• Product Name: 5-Bromo-thiophene-2-carboxylic acid methyl ester
• Synonyms: 5-Bromo-thiophene-2-carboxylic acid methyl ester;Methyl 5-bromo-2-thiophenecarboxylate;2-Thiophenecarboxylic acid, 5-bromo-, methyl ester;methyl 5-bromothiophene-2-carboxylate;5-broMo-;Methyl 2-broMothiophene-5...;Methyl 2-broMothiophene-5-carboxylate
• CAS NO: 62224-19-5
• Molecular Formula: C₆H₅BrO₂S
• Molecular Weight: 221.0717
• Product Categories: API intermediates
• Mol File: 62224-19-5.mol
• Article Data: 54

Chemical Properties

• Melting Point: 87-88℃
• Boiling Point: 251.868 °C at 760 mmHg
• Flash Point: 106.126 °C
• Appearance: /
• Density: 1.662 g/cm³
• Vapor Pressure: 0.02mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-Bromo-thiophene-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-thiophene-2-carboxylic acid methyl ester(62224-19-5)
• EPA Substance Registry System: 5-Bromo-thiophene-2-carboxylic acid methyl ester(62224-19-5)

Safety Data

• Hazardous Substances Data: 62224-19-5(Hazardous Substances Data)

Usage

Uses

Methyl 5-Bromo-2-thiophenecarboxylate is used as a reagent in the synthesis of trisubstituted isoxazole derivatives which are novel nonsteroidal antagonists of Farnesoid X Receptor (FXR). FXR plays an important role in regulation of cholesterol, lipid and glucose metabolism.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 35, p. 1109, 1992 DOI: 10.1021/jm00084a016

InChI:InChI=1/C6H5BrO2S/c1-9-6(8)4-2-3-5(7)10-4/h2-3H,1H3

Upstream product

• 67-56-1 methanol 
• 31555-60-9 5-bromothiophene-2-carbonyl chloride 
• 5380-42-7 thiophene-2-carboxylic acid methyl ester 
• 1003-09-4 2-bromothiophene 
• 56-23-5 tetrachloromethane 
• 527-72-0 2-thiophenylcarboxylic acid 
• 74-88-4 methyl iodide 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 77-78-1 dimethyl sulfate 
• 124-38-9 carbon dioxide 
• 558-13-4 carbon tetrabromide 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 75-36-5 acetyl chloride 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 

Downstream Products

• 38239-32-6 methyl 5-bromo-4-nitrothiophene-2-carboxylate 
• 773873-74-8 methyl 5-(pyridin-2-yl)thiophene-2-carboxylate 
• 1103394-49-5 (R)-tert-butyl 2-(5-methoxycarbonylthiophen-2-yl)pyrrolidine-1-carboxylate 
• 5380-42-7 thiophene-2-carboxylic acid methyl ester 
• 935264-52-1 methyl 5-(2-(7-phenylheptanoyl)oxazol-5-yl)thiophene-2-carboxylate 
• 893733-15-8 C₁₁H₇ClO₂S 

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