Acetic acid (1R,2S)-3-acetoxy-2-acetylsulfanyl-1-(4-bromo-benzyloxymethyl)-propyl ester

Base Information

• Chemical Name: Acetic acid (1R,2S)-3-acetoxy-2-acetylsulfanyl-1-(4-bromo-benzyloxymethyl)-propyl ester
• CAS No.: 177584-45-1
• Molecular Formula: C₁₇H₂₁BrO₆S
• Molecular Weight: 433.32
• Mol file: 177584-45-1.mol

Synonyms:Acetic acid (1R,2S)-3-acetoxy-2-acetylsulfanyl-1-(4-bromo-benzyloxymethyl)-propyl ester

Chemical Property of Acetic acid (1R,2S)-3-acetoxy-2-acetylsulfanyl-1-(4-bromo-benzyloxymethyl)-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (1R,2S)-3-acetoxy-2-acetylsulfanyl-1-(4-bromo-benzyloxymethyl)-propyl ester

There total 5 articles about Acetic acid (1R,2S)-3-acetoxy-2-acetylsulfanyl-1-(4-bromo-benzyloxymethyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

sodium acetate (127-09-3) + acetic anhydride (108-24-7) + Acetic acid (R)-2-(4-bromo-benzyloxy)-1-(R)-thiiranyl-ethyl ester (177287-18-2) → Acetic acid (1R,2S)-3-acetoxy-2-acetylsulfanyl-1-(4-bromo-benzyloxymethyl)-propyl ester (177584-45-1)

Guidance literature:

In acetic acid; at 130 ℃; for 48h;

DOI:10.1021/jo960009c

Reference yield:

(2S,3R)-4-(p-bromobenzyloxy)-2,3-epoxybutan-1-ol (108267-97-6) → Acetic acid (1R,2S)-3-acetoxy-2-acetylsulfanyl-1-(4-bromo-benzyloxymethyl)-propyl ester (177584-45-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 38 percent / aq. NaOH / tetrahydrofuran / 3 h / Ambient temperature

2: puridine / 0.5 h / Ambient temperature

3: thiourea / methanol / 3 h / Ambient temperature

4: 79 percent / acetic acid / 48 h / 130 °C

With pyridine; sodium hydroxide; thiourea; In tetrahydrofuran; methanol; acetic acid;

DOI:10.1021/jo960009c

Reference yield:

(R)-2-(4-Bromo-benzyloxy)-1-(R)-oxiranyl-ethanol (177287-28-4) → Acetic acid (1R,2S)-3-acetoxy-2-acetylsulfanyl-1-(4-bromo-benzyloxymethyl)-propyl ester (177584-45-1)

Guidance literature:

Multi-step reaction with 3 steps

1: puridine / 0.5 h / Ambient temperature

2: thiourea / methanol / 3 h / Ambient temperature

3: 79 percent / acetic acid / 48 h / 130 °C

With pyridine; thiourea; In methanol; acetic acid;

DOI:10.1021/jo960009c

upstream raw materials:

sodium acetate

acetic anhydride

Acetic acid (R)-2-(4-bromo-benzyloxy)-1-(R)-thiiranyl-ethyl ester

(2S,3R)-4-(p-bromobenzyloxy)-2,3-epoxybutan-1-ol