Technology Process of ethyl (4R)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-phenylpentanoate
There total 5 articles about ethyl (4R)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-phenylpentanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 93 percent / 0.5 h / 135 - 140 °C
2: 98 percent / (COCl)2; DMSO; DIPEA / CH2Cl2 / -45 - -30 °C
3: t-BuOK / tetrahydrofuran / 2 h / 20 °C
4: 1.25 g / NiCl2*6H2O; NaBH4 / methanol; tetrahydrofuran / 0.17 h / -30 °C
With
sodium tetrahydroborate; oxalyl dichloride; potassium tert-butylate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; nickel dichloride;
In
tetrahydrofuran; methanol; dichloromethane;
2: Swern oxidation / 3: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jo071081l
- Guidance literature:
-
With
sodium tetrahydroborate; nickel dichloride;
In
tetrahydrofuran; methanol;
at -30 ℃;
for 0.166667h;
DOI:10.1021/jo071081l
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 93 percent / 0.5 h / 135 - 140 °C
2: 98 percent / (COCl)2; DMSO; DIPEA / CH2Cl2 / -45 - -30 °C
3: t-BuOK / tetrahydrofuran / 2 h / 20 °C
4: 1.25 g / NiCl2*6H2O; NaBH4 / methanol; tetrahydrofuran / 0.17 h / -30 °C
With
sodium tetrahydroborate; oxalyl dichloride; potassium tert-butylate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; nickel dichloride;
In
tetrahydrofuran; methanol; dichloromethane;
2: Swern oxidation / 3: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jo071081l
