1-(4-(4-chlorophenyl)but-3-yn-2-yloxy)-3-(2,4-dichlorophenyl)propan-2-one

Base Information

Chemical Name:1-(4-(4-chlorophenyl)but-3-yn-2-yloxy)-3-(2,4-dichlorophenyl)propan-2-one
CAS No.:1346682-38-9
Molecular Formula:C₁₉H₁₅Cl₃O₂
Molecular Weight:381.686
Hs Code.:

Synonyms:1-(4-(4-chlorophenyl)but-3-yn-2-yloxy)-3-(2,4-dichlorophenyl)propan-2-one

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Chemical Property of 1-(4-(4-chlorophenyl)but-3-yn-2-yloxy)-3-(2,4-dichlorophenyl)propan-2-one

Chemical Property:

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Technology Process of 1-(4-(4-chlorophenyl)but-3-yn-2-yloxy)-3-(2,4-dichlorophenyl)propan-2-one

There total 5 articles about 1-(4-(4-chlorophenyl)but-3-yn-2-yloxy)-3-(2,4-dichlorophenyl)propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 637-87-6
1-Chloro-4-iodobenzene

: 1346682-26-5
1-(but-3-yn-2-yloxy)-3-(2,4-dichlorophenyl)propan-2-one

: 1346682-38-9
1-(4-(4-chlorophenyl)but-3-yn-2-yloxy)-3-(2,4-dichlorophenyl)propan-2-one

Guidance literature:: 1-Chloro-4-iodobenzene; With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; for 0.5h;

1-(but-3-yn-2-yloxy)-3-(2,4-dichlorophenyl)propan-2-one; at 20 ℃;
DOI:10.1021/jo201918d

Reference yield:

: 1346682-19-6
2-((but-3-yn-2-yloxy)methyl)-3-(2,4-dichlorophenyl)oxirane

: 1346682-38-9
1-(4-(4-chlorophenyl)but-3-yn-2-yloxy)-3-(2,4-dichlorophenyl)propan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 0.5 h / 20 °C

2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 0.5 h

2.2: 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(II) bis(trifluoromethanesulfonate); triethylamine; In dichloromethane; 1.1: Meinwald rearrangement / 2.1: Sonogashira coupling / 2.2: Sonogashira coupling;
DOI:10.1021/jo201918d

Reference yield:

: 1346682-13-0
(E)-1-(3-bromoprop-1-enyl)-2,4-dichlorobenzene

: 1346682-38-9
1-(4-(4-chlorophenyl)but-3-yn-2-yloxy)-3-(2,4-dichlorophenyl)propan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

3.1: copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 0.5 h / 20 °C

4.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / 0.5 h

4.2: 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(II) bis(trifluoromethanesulfonate); sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; mineral oil; 3.1: Meinwald rearrangement / 4.1: Sonogashira coupling / 4.2: Sonogashira coupling;
DOI:10.1021/jo201918d