2-[4-(methylamino)phenyl]-6-(3-fluoro-2-hydroxypropoxy)benzo[b]thiophene

Base Information

Chemical Name:2-[4-(methylamino)phenyl]-6-(3-fluoro-2-hydroxypropoxy)benzo[b]thiophene
CAS No.:1301255-93-5
Molecular Formula:C₁₈H₁₈FNO₂S
Molecular Weight:331.411
Hs Code.:

Synonyms:2-[4-(methylamino)phenyl]-6-(3-fluoro-2-hydroxypropoxy)benzo[b]thiophene

Suppliers and Price of 2-[4-(methylamino)phenyl]-6-(3-fluoro-2-hydroxypropoxy)benzo[b]thiophene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[4-(methylamino)phenyl]-6-(3-fluoro-2-hydroxypropoxy)benzo[b]thiophene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[4-(methylamino)phenyl]-6-(3-fluoro-2-hydroxypropoxy)benzo[b]thiophene

There total 11 articles about 2-[4-(methylamino)phenyl]-6-(3-fluoro-2-hydroxypropoxy)benzo[b]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1301256-86-9
2-[4-(N-methyl-N-Boc-amino)phenyl]-6-[3-methanesulfonyloxy-2-(tetrahydropyran-2-yloxy)propoxy]benzo[b]thiophene

: 1301255-93-5
2-[4-(methylamino)phenyl]-6-(3-fluoro-2-hydroxypropoxy)benzo[b]thiophene

Guidance literature:: 2-[4-(N-methyl-N-Boc-amino)phenyl]-6-[3-methanesulfonyloxy-2-(tetrahydropyran-2-yloxy)propoxy]benzo[b]thiophene; With tetrabutyl ammonium fluoride; In tert-Amyl alcohol; water; at 100 ℃; for 6h;

With hydrogenchloride; In tetrahydrofuran; at 80 ℃; for 0.5h;

Reference yield:

: C₂₈H₃₄FNO₅S

: 1301255-93-5
2-[4-(methylamino)phenyl]-6-(3-fluoro-2-hydroxypropoxy)benzo[b]thiophene

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 80 ℃; for 0.5h;
DOI:10.1016/j.bmc.2016.03.034

Reference yield:

: 19301-39-4
1-benzothiophen-6-ol

: 1301255-93-5
2-[4-(methylamino)phenyl]-6-(3-fluoro-2-hydroxypropoxy)benzo[b]thiophene

Guidance literature:: Multi-step reaction with 9 steps

1.1: 1H-imidazole / dichloromethane / 1 h / 0 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1.25 h / -78 - 20 °C / Inert atmosphere

2.2: 3 h / -78 - 20 °C

3.1: potassium carbonate / palladium diacetate / PEG 400 / 3 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

6.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / 1,4-diaza-bicyclo[2.2.2]octane / water / 24 h / 45 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -10 °C

8.1: pyridinium p-toluenesulfonate / dichloromethane / 17 h / 20 °C

9.1: tetrabutyl ammonium fluoride / water; tert-Amyl alcohol / 6 h / 100 °C

9.2: 0.5 h / 80 °C

With 1H-imidazole; osmium(VIII) oxide; n-butyllithium; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; potassium carbonate; caesium carbonate; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate; In tetrahydrofuran; tert-Amyl alcohol; hexane; dichloromethane; water; N,N-dimethyl-formamide; PEG 400;