Technology Process of 6-hydroxy-5(R*)-(p-tolylsulfonyl)-β-copaene
There total 6 articles about 6-hydroxy-5(R*)-(p-tolylsulfonyl)-β-copaene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
p-toluene sulfinic acid; water;
In
acetonitrile;
for 12h;
Heating;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) n-butyllithium / 1.) hexane, THF, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 1.5 h
2: 37 percent / Bu3SnH, azobis(isobutyronitrile) (AIBN) / benzene / 48 h / Heating
3: 79 percent / p-toluenesulfinic acid, water / acetonitrile / 12 h / Heating
With
n-butyllithium; p-toluene sulfinic acid; 2,2'-azobis(isobutyronitrile); water; tri-n-butyl-tin hydride;
In
acetonitrile; benzene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 62 percent / NaI / dimethylformamide / 1.) 80 deg C, 10 h, 2.) 40 deg C, 12 h
2: 1.) n-butyllithium / 1.) hexane, THF, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 1.5 h
3: 37 percent / Bu3SnH, azobis(isobutyronitrile) (AIBN) / benzene / 48 h / Heating
4: 79 percent / p-toluenesulfinic acid, water / acetonitrile / 12 h / Heating
With
n-butyllithium; p-toluene sulfinic acid; 2,2'-azobis(isobutyronitrile); water; tri-n-butyl-tin hydride; sodium iodide;
In
N,N-dimethyl-formamide; acetonitrile; benzene;
