N-(cyclopropylmethyl)-4-(2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide

Base Information

Chemical Name:N-(cyclopropylmethyl)-4-(2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide
CAS No.:1352620-10-0
Molecular Formula:C₂₉H₃₃N₇O₂
Molecular Weight:511.627
Hs Code.:

Synonyms:N-(cyclopropylmethyl)-4-(2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide

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Chemical Property of N-(cyclopropylmethyl)-4-(2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide

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Technology Process of N-(cyclopropylmethyl)-4-(2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide

There total 7 articles about N-(cyclopropylmethyl)-4-(2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1146950-78-8
1-(3-methoxyl-4-bromophenyl)-4-methylpiperazine

: 1352620-78-0
4-(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(cyclopropylmethyl)benz-amide

: 1352620-10-0
N-(cyclopropylmethyl)-4-(2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide

Guidance literature:: With sodium t-butanolate; chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)methyl-t-butylether adduct; XPhos; In toluene; at 130 ℃; Inert atmosphere;

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1352620-10-0
N-(cyclopropylmethyl)-4-(2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1,4-dioxane / 2 h / 20 °C

2: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol / 2 h / 60 °C

3: potassium carbonate / triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / propan-1-ol / 1 h / Reflux

4: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 72 h / 20 °C

5: sodium t-butanolate / XPhos; chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)methyl-t-butylether adduct / toluene / 130 °C / Inert atmosphere

With hydroxylamine hydrochloride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; bis-triphenylphosphine-palladium(II) chloride; chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)methyl-t-butylether adduct; triphenylphosphine; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; propan-1-ol; toluene;

Reference yield:

: 6968-76-9
1-(3-methoxyphenyl)piperazine dihydrochloride

: 1352620-10-0
N-(cyclopropylmethyl)-4-(2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}[1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate; acetic acid / water / 5 °C

1.2: 1 h / 0 °C

2.1: sodium cyanoborohydride; acetic acid / water; methanol / 16 h / 60 °C

3.1: sodium t-butanolate / XPhos; chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)methyl-t-butylether adduct / toluene / 130 °C / Inert atmosphere

With sodium acetate; sodium cyanoborohydride; acetic acid; sodium t-butanolate; chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)methyl-t-butylether adduct; XPhos; In methanol; water; toluene;