(R)?2?bromo?1?(4′?methoxyphenyl)ethanol

Base Information

• Chemical Name: (R)?2?bromo?1?(4′?methoxyphenyl)ethanol
• CAS No.: 117465-37-9
• Molecular Formula: C₉H₁₁BrO₂
• Molecular Weight: 231.089
• Mol file: 117465-37-9.mol

Synonyms:(R)?2?bromo?1?(4′?methoxyphenyl)ethanol

Chemical Property of (R)?2?bromo?1?(4′?methoxyphenyl)ethanol

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)?2?bromo?1?(4′?methoxyphenyl)ethanol

There total 7 articles about (R)?2?bromo?1?(4′?methoxyphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-Bromo-4'-methoxyacetophenone (2632-13-5) → (R)?2?bromo?1?(4′?methoxyphenyl)ethanol (117465-37-9,19922-83-9)

Guidance literature:

With formic acid; C₃₁H₃₃N₂O₃RuS; potassium formate; In water; ethyl acetate; at 60 ℃; for 4h; enantioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201701227

Reference yield: 86.0%

1-bromo-2-(4-methoxyphenyl)acetylene (33675-41-1) → (R)?2?bromo?1?(4′?methoxyphenyl)ethanol (117465-37-9,19922-83-9)

Guidance literature:

With formic acid; water; triethylamine; In 1,2-dichloro-ethane; enantioselective reaction;

DOI:10.1039/c6cc09008g

Reference yield: 85.0%

2-Bromo-4'-methoxyacetophenone (2632-13-5) → (R)?2?bromo?1?(4′?methoxyphenyl)ethanol (117465-37-9,19922-83-9) + 1-(4-methoxyphenyl)ethanone (100-06-1)

Guidance literature:

With C₃₁H₃₃ClN₂O₈RhS₃^(2-)*2Na⁽¹⁺⁾; sodium formate; In water; at 40 ℃; for 1h; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c2ra22432a

upstream raw materials:

2-bromo-1-(4-methoxyphenyl)ethanol

2-Bromo-4'-methoxyacetophenone

4-chlorophenyl acetate

1-bromo-2-(4-methoxyphenyl)acetylene

Downstream raw materials:

(R)?4?methoxyphenyloxirane

(R)-β-azido-α-(4-methoxyphenyl)ethanol

Refernces

• 1、 Bandini, Marco,Cozzi, Pier Giorgio,Negro, Lucia,Umani-Ronchi, Achille. "Enantioselective reduction of ketones with triethoxysilane catalyzed by chiral bis-oxazoline titanium complexes". . p. 39 - 40. Retrieved 1999.
• 2、 Sawada, Erika,Nakata, Kenya. "Chiral guanidine catalyzed acylative kinetic resolution of racemic 2-bromo-1-arylethanols". . p. 371 - 373. Retrieved 2021/03/16.
• 3、 Hosseinzadeh, Rahman,Mohadjerani, Maryam,Mesgar, Sakineh. "Asymmetric synthesis of α-bromohydrins by carrot root as biocatalyst and conversion to enantiopure β-hydroxytriazoles and styrene oxides using click chemistry and SN2 ring-closure". . p. 583 - 591. Retrieved 2019/02/17.