6-(4-bromophenyl)-4-(N-(4-methoxyphenyl)benzamido)pyridin-3-yl benzoate

Base Information

• Chemical Name: 6-(4-bromophenyl)-4-(N-(4-methoxyphenyl)benzamido)pyridin-3-yl benzoate
• CAS No.: 1426821-61-5
• Molecular Formula: C₃₂H₂₃BrN₂O₄
• Molecular Weight: 579.45
• Mol file: 1426821-61-5.mol

Synonyms:6-(4-bromophenyl)-4-(N-(4-methoxyphenyl)benzamido)pyridin-3-yl benzoate

Chemical Property of 6-(4-bromophenyl)-4-(N-(4-methoxyphenyl)benzamido)pyridin-3-yl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-bromophenyl)-4-(N-(4-methoxyphenyl)benzamido)pyridin-3-yl benzoate

There total 5 articles about 6-(4-bromophenyl)-4-(N-(4-methoxyphenyl)benzamido)pyridin-3-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

p-methoxyphenylisonitrile (10349-38-9) + N-(1-(4-bromophenyl)vinyl)-N-(2-oxoethyl)benzamide (1426821-30-8) + benzoyl chloride (98-88-4) → 6-(4-bromophenyl)-4-(N-(4-methoxyphenyl)benzamido)pyridin-3-yl benzoate (1426821-61-5)

Guidance literature:

p-methoxyphenylisonitrile; N-(1-(4-bromophenyl)vinyl)-N-(2-oxoethyl)benzamide; With zinc trifluoromethanesulfonate; In acetonitrile; at 20 ℃; Molecular sieve;

benzoyl chloride; With triethylamine; In acetonitrile; for 2h;

DOI:10.1021/ja401701x

Reference yield:

p-methoxyphenylisonitrile (10349-38-9) + 4-methyl-N-(2-oxoethyl)-N-(1-phenylvinyl)benzamide (1426821-38-6) + N-(1-(4-bromophenyl)vinyl)-N-(2-oxoethyl)benzamide (1426821-30-8) + benzoyl chloride (98-88-4) → 6-(4-bromophenyl)-4-(N-(4-methoxyphenyl)benzamido)pyridin-3-yl benzoate (1426821-61-5) + 4-(N-(4-methoxyphenyl)benzamido)-6-phenylpyridin-3-yl 4-methylbenzoate (1426821-75-1)

Guidance literature:

p-methoxyphenylisonitrile; 4-methyl-N-(2-oxoethyl)-N-(1-phenylvinyl)benzamide; N-(1-(4-bromophenyl)vinyl)-N-(2-oxoethyl)benzamide; With zinc trifluoromethanesulfonate; In acetonitrile; at 20 ℃; Molecular sieve;

benzoyl chloride; With triethylamine; at 20 ℃;

DOI:10.1021/ja401701x

Reference yield:

4-(N-(4-methoxyphenyl)benzamido)-6-phenylpyridin-3-yl benzoate (1426821-45-5) → 6-(4-bromophenyl)-4-(N-(4-methoxyphenyl)benzamido)pyridin-3-yl benzoate (1426821-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ozone / dichloromethane; methanol / 2.25 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 - 20 °C / Inert atmosphere

2.1: zinc trifluoromethanesulfonate / acetonitrile / 20 °C / Molecular sieve

2.2: 2 h

With zinc trifluoromethanesulfonate; ozone; In methanol; dichloromethane; acetonitrile;

DOI:10.1021/ja401701x

upstream raw materials:

p-methoxyphenylisonitrile

4-methyl-N-(2-oxoethyl)-N-(1-phenylvinyl)benzamide

N-(1-(4-bromophenyl)vinyl)-N-(2-oxoethyl)benzamide

benzoyl chloride