ethyl 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)amino]sulfonyl}benzoate

Base Information

Chemical Name:ethyl 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)amino]sulfonyl}benzoate
CAS No.:1400698-57-8
Molecular Formula:C₂₇H₂₂F₄N₂O₅S
Molecular Weight:562.542
Hs Code.:

Synonyms:ethyl 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)amino]sulfonyl}benzoate

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Chemical Property of ethyl 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)amino]sulfonyl}benzoate

Chemical Property:

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Technology Process of ethyl 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)amino]sulfonyl}benzoate

There total 3 articles about ethyl 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)amino]sulfonyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197231-80-3
ethyl 3-fluoro-4-(trifluoromethoxy)benzoate

: 1400698-57-8
ethyl 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)amino]sulfonyl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 5.5 h / 0 - 20 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;

Reference yield:

: 886498-89-1
3-fluoro-4-(trifluoromethoxy)benzoic acid

: 1400698-57-8
ethyl 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)amino]sulfonyl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 5.5 h / 0 - 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;

Reference yield:

: 10486-51-8
4-ethoxycarbonylbenzenesulfonyl chloride

: 1400698-57-8
ethyl 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)amino]sulfonyl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 3 h / 80 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

With pyridine; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;