sodium 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)-amino]sulfonyl}benzoate

Base Information

Chemical Name:sodium 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)-amino]sulfonyl}benzoate
CAS No.:1400698-58-9
Molecular Formula:C₂₅H₁₇F₄N₂O₅S*Na
Molecular Weight:556.47
Hs Code.:

Synonyms:sodium 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)-amino]sulfonyl}benzoate

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Chemical Property of sodium 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)-amino]sulfonyl}benzoate

Chemical Property:

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Technology Process of sodium 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)-amino]sulfonyl}benzoate

There total 5 articles about sodium 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)-amino]sulfonyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1400698-57-8
ethyl 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)amino]sulfonyl}benzoate

: 1400698-58-9
sodium 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)-amino]sulfonyl}benzoate

Guidance literature:: With water; sodium hydroxide; In ethanol; for 1h; Reflux;

Reference yield:

: 1197231-80-3
ethyl 3-fluoro-4-(trifluoromethoxy)benzoate

: 1400698-58-9
sodium 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)-amino]sulfonyl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 5.5 h / 0 - 20 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

3: sodium hydroxide; water / ethanol / 1 h / Reflux

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; water; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol;

Reference yield:

: 886498-89-1
3-fluoro-4-(trifluoromethoxy)benzoic acid

: 1400698-58-9
sodium 4-{[[3-fluoro-4-(trifluoromethoxy)benzyl](4-methylisoquinolin-3-yl)-amino]sulfonyl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 5.5 h / 0 - 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

4: sodium hydroxide; water / ethanol / 1 h / Reflux

With lithium aluminium tetrahydride; thionyl chloride; di-isopropyl azodicarboxylate; water; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol;