[5S,5(4'S,5'S)]-5-(1'-benzyl-4',5'-dihydro-4',5'-diphenylimidazol-2'-yl)-5-phenylhexan-1-ol benzyl ether

Base Information

Chemical Name:[5S,5(4'S,5'S)]-5-(1'-benzyl-4',5'-dihydro-4',5'-diphenylimidazol-2'-yl)-5-phenylhexan-1-ol benzyl ether
CAS No.:216172-84-8
Molecular Formula:C₄₁H₄₂N₂O
Molecular Weight:578.797
Hs Code.:

Synonyms:[5S,5(4'S,5'S)]-5-(1'-benzyl-4',5'-dihydro-4',5'-diphenylimidazol-2'-yl)-5-phenylhexan-1-ol benzyl ether

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Chemical Property of [5S,5(4'S,5'S)]-5-(1'-benzyl-4',5'-dihydro-4',5'-diphenylimidazol-2'-yl)-5-phenylhexan-1-ol benzyl ether

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Technology Process of [5S,5(4'S,5'S)]-5-(1'-benzyl-4',5'-dihydro-4',5'-diphenylimidazol-2'-yl)-5-phenylhexan-1-ol benzyl ether

There total 1 articles about [5S,5(4'S,5'S)]-5-(1'-benzyl-4',5'-dihydro-4',5'-diphenylimidazol-2'-yl)-5-phenylhexan-1-ol benzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 100-39-0
benzyl bromide

: [5S-5(4'S,5'S)]-5-(4',5'-dihydro-4',5'-diphenyl-1H-imidazol-2'-yl)-5-phenylhexan-1-ol

: 216172-84-8
[5S,5(4'S,5'S)]-5-(1'-benzyl-4',5'-dihydro-4',5'-diphenylimidazol-2'-yl)-5-phenylhexan-1-ol benzyl ether

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 20 ℃; for 7h;
DOI:10.1021/jo980289r

Reference yield:

: 216172-84-8
[5S,5(4'S,5'S)]-5-(1'-benzyl-4',5'-dihydro-4',5'-diphenylimidazol-2'-yl)-5-phenylhexan-1-ol benzyl ether

: 67074-38-8
(S)-(-)-2-methyl-2-phenylcyclohexanone

Guidance literature:: Multi-step reaction with 7 steps

1: BaO / various solvent(s) / 4 h / 120 °C

2: sodium borohydride / ethanol / 0.58 h / 0 - 20 °C

3: 448 mg / aq. HCl / ethanol / 0.5 h / 0 - 5 °C

4: Ca(OCl)2; acetic acid / 34 h / 0 - 20 °C

5: 270 mg / Na₂CO₃; H₂ / Pd(OH)2 / ethyl acetate / 1.5 h / 20 °C

6: 87 percent / CBr₄; PPh₃ / diethyl ether / 18 h / 20 °C

7: 61 percent / diiodomethane; Sm; HMPA / tetrahydrofuran / 2.5 h / 0 - 20 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; samarium; sodium tetrahydroborate; calcium hypochlorite; diiodomethane; carbon tetrabromide; hydrogen; sodium carbonate; acetic acid; triphenylphosphine; barium(II) oxide; palladium dihydroxide; In tetrahydrofuran; diethyl ether; ethanol; ethyl acetate; 1: Methylation / 2: Reduction / 3: Hydrolysis / 4: Oxidation / 5: Hydrogenolysis / 6: Substitution / 7: Cyclization;
DOI:10.1021/jo980289r

Reference yield:

: 216172-84-8
[5S,5(4'S,5'S)]-5-(1'-benzyl-4',5'-dihydro-4',5'-diphenylimidazol-2'-yl)-5-phenylhexan-1-ol benzyl ether

: 216172-86-0
methyl (S)-6-hydroxy-2-methyl-2-phenylhexanoate

Guidance literature:: Multi-step reaction with 5 steps

1: BaO / various solvent(s) / 4 h / 120 °C

2: sodium borohydride / ethanol / 0.58 h / 0 - 20 °C

3: 448 mg / aq. HCl / ethanol / 0.5 h / 0 - 5 °C

4: Ca(OCl)2; acetic acid / 34 h / 0 - 20 °C

5: 270 mg / Na₂CO₃; H₂ / Pd(OH)2 / ethyl acetate / 1.5 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; calcium hypochlorite; hydrogen; sodium carbonate; acetic acid; barium(II) oxide; palladium dihydroxide; In ethanol; ethyl acetate; 1: Methylation / 2: Reduction / 3: Hydrolysis / 4: Oxidation / 5: Hydrogenolysis;
DOI:10.1021/jo980289r